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Fig. 2 | BMC Systems Biology

Fig. 2

From: Paracrine and autocrine regulation of gene expression by Wnt-inhibitor Dickkopf in wild-type and mutant hepatocytes

Fig. 2

Schematic representation of the mathematical model. a: The spatial model considers a single row of 21 adjacent hepatocytes. Each hepatocyte harbours the identical structure of the Wnt/ β-catenin signalling pathway shown in (b), but differs in its total APC concentration. Dkk may diffuse along the row of cells through the space of Disse as indicated by the green arrows. b: Model scheme exemplarily shown for neighbouring hepatocytes. The hepatocytes and their nuclei are indicated by light and dark brown backgrounds, respectively. The reaction scheme is identical in each of the 21 cells. The model is subdivided into three modules: the receptor module, the signalling module, and the target gene module. Components in a complex are separated by slashes. One-headed arrows denote reactions taking place in the indicated direction; double-headed arrows illustrate reversible binding reactions. Dashed arrows represent activation mechanisms; the dashed line ending in T-shape denotes inhibition. The number next to an arrow specifies the number of the reaction. Model equations and the reference parameter set are provided in the Additional file 1 (Section A). Note that Dkk can diffuse (green arrow) to all neighbouring hepatocytes on the right and left side

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