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Fig. 4 | BMC Systems Biology

Fig. 4

From: Paracrine and autocrine regulation of gene expression by Wnt-inhibitor Dickkopf in wild-type and mutant hepatocytes

Fig. 4

Different combinations of Wnt and APC gradients yield qualitatively different target gene mRNA expression profiles. Shown are the concentrations of total Wnt (upper row) and total APC (middle row) as well as the resulting target gene mRNA concentrations (lower row) along the porto-central axis. a: Constant total Wnt (1 nM) and a gradient of total APC increasing exponentially from PC (20 nM) to PP (100 nM). This represents the reference parameter set; further details are given in the Additional file 1 (Section A). b: Constant total APC (100 nM) and a gradient of total Wnt increasing exponentially from PC (1 nM) to PP (5 nM). c: Gradients of total Wnt and total APC increasing exponentially from PC (1 nM and 20 nM, respectively) to PP (5 nM and 100 nM, respectively). Both total Wnt and total APC concentrations change five-fold along the porto-central axis. d: Gradients of total Wnt and total APC, increasing exponentially from PC (0.1 nM and 50 nM, respectively) to PP (5 nM and 100 nM, respectively). Total Wnt concentration changes 25 times stronger than that of total APC along the porto-central axis. e: A gradient of total Wnt decreasing exponentially from PC (5 nM) to PP (1 nM) in combination with a gradient of total APC increasing exponentially from PC (20 nM) to PP (100 nM)

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