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Fig. 2 | BMC Systems Biology

Fig. 2

From: Reconstructing cancer drug response networks using multitask learning

Fig. 2

A merged network for the output of multi-task learning using data from breast cancer (lightest shade), prostate cancer (medium shade), and melanoma (darkest shade). Top nodes (red shades): Sources. These proteins are either known to interact with the drugs we tested or determined to be sources using the correlation analysis between drug expression response and KO response as described in Methods. Middle nodes (blue shades): Signaling proteins. These proteins are determined to belong to key pathways connecting sources and TFs. Bottom nodes (green shades): TFs. These proteins regulate a large subset of the DE genes in the different cell types following treatment with the drugs being tested. Note that while sources tend to be cell type specific, most signaling and TF proteins are shared between two or all three cell types indicating that several of the response pathways may be shared between the different cancer types

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