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Table 3 Recurrent Genes for Breast Cancer, Prostate Cancer and Melanoma

From: Reconstructing cancer drug response networks using multitask learning

Tumor type Gene Potential role
Breast cancer MED1 [35] Co-activator with Her2 of estrogen
   receptor (ER) in α-positive tumors.
  HDAC3 [34] Histone deacetylase involved in the
   oncogenic tumorigenesis of breast
   cancer.
  WEE1 [63] Inhibition of WEE1 causes increased
   cell death in breast cell lines
  GNAS [36] GNAS locus identified as a driver in
   20q amplified breast cancer
  CDKN1B [64] Associated with increased breast
   cancer risks
  APP [65] Androgen-induced gene that
   promotes proliferation activity of
   breast cancer cells.
Prostate cancer PTPN6 [66] Tumoral Prostate Shows Different
   Expression Pattern
  PDGFRB [37] Blockade of PDGF signaling induced
   apoptosis in metastatic PCa cells.
  TAB2 [67] Deletion of MAP3K7 at 6q12-22 is
   associated with early PSA recurrence
  SQSTM1 [68] PCa cell lines have high p62/SQSTM1
   levels required for cell survival
  COPS2 [69] Alien interacts with the human
   androgen receptor and inhibits
   prostate cancer cell growth
  CTBP1 [38] Dysregulated expression of CTBP1
   plays an important role in prostate
   cancer progression
Melanoma TNFRSF10A [70] In vitro IFN- β and TRAIL/Apo2L
   combination treatment had more
   potent apoptotic effects
  ZFP36 [40] Loss of TTP represents a key event
   in the establishment of melanomas
  PRKCD [71] Overexpression in BL6 murine
   melanoma cells inhibits the
   proliferative capacity in vivo
  TLE1 [72] Diagnostic Immunohistochemical
   Marker for Synovial Sarcoma
  XRCC5 [39] One of only two DNA repair and
   replication proteins which are
   prognostic for melanoma