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Fig. 5 | BMC Systems Biology

Fig. 5

From: Genotype-driven identification of a molecular network predictive of advanced coronary calcium in ClinSeq® and Framingham Heart Study cohorts

Fig. 5

Network of genes derived from GeneMANIA (based on 244 studies in humans) using the most predictive set of SNPs in this study. The connections in pink are derived from gene coexpression data, whereas the connections in green are derived from genetic interaction data from the literature. The inner circle is composed of genes on which the subset of SNPs in SNP Set-2 leading to optimal performance in both cohorts are present, whereas the genes forming the outer circle are additional genes identified by GeneMANIA. The thicknesses of the links (or edges) between the genes are proportional to the interaction strengths, whereas the node size for each gene is proportional to the rank of the gene based on its importance (or gene score) within the network. All interactions within this network are listed in Additional file 1: Table S8

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