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Table 4 Enriched diseases and biological functions (in the network of genes derived from GeneMANIA) with p-values ranging between 1.0E-4 and 1.0E-2 as identified by IPA based on Fisher’s exact test

From: Genotype-driven identification of a molecular network predictive of advanced coronary calcium in ClinSeq® and Framingham Heart Study cohorts

Category

Disease or function

Genes

p-value

Connective tissue development and function

Quantity of adipose tissue

ARID5B, CYB5R4

3.58E-4

  

RETN, TLR5

 

Connective tissue development and function

Differentiation of adipocytes

ARID5B, EGLN1

8.82E-4

  

NIPBL, RETN

 

Cardiovascular disease

Angiectasis of blood vessel

EGLN1

9.87E-4

Cardiovascular system development and function

Area of capillary vessel

EGLN1

9.87E-4

Hematological system development and function

Cell division of

AIMP1

9.87E-4

 

peripheral blood lymphocytes

  

Cardiovascular disease, endocrine system disorders,

Susceptibility to insulin

RETN

9.87E-4

Metabolic disease

resistance-related hypertension

  

Cardiac necrosis, cell death and survival

Cell death of heart tissue

EGLN1

1.97E-3

Cellular movement

Migration of connective tissue cells

AIMP1, ARID5B

2.14E-3

  

RETN

 

Carbohydrate metabolism, cellular function

Homeostasis of D-glucose

CYB5R4, RETN

2.46E- 3

and maintenance

 

TLR5

 

Nucleic acid metabolism

Conversion of NAD+

NNT

2.96E- 3

Cardiovascular system development and function

Tethering of endothelial cell lines

FUT3

2.96E-3

Cellular compromise, inflammatory response

Degranulation of beta islet cells

CYB5R4

3.94E-3

Cardiovascular system development and function

Density of blood vessel tissue

AIMP1

3.94E-3

Endocrine system disorders, hematological disease

Onset of hyperglycemia

CYB5R4

3.94E-3

Metabolic disease

   

Carbohydrate metabolism

Tolerance of D-glucose

CYB5R4

4.93E- 3

Cardiovascular system development and function

Angiogenesis of heart

EGLN1

5.91E-3

Cardiovascular system development and function

Density of blood vessel

AIMP1, EGLN1

5.96E-3

Immune cell trafficking, inflammatory response

Adhesion of neutrophils

ADGRE2 (EMR2)

7.52E-3

Hematological system development and function

 

TLR5

 

Endocrine system development and function

Insulin sensitivity of liver

RETN

7.87E-3

Hepatic system development and function

   

Nucleic acid metabolism

Metabolism of NADPH

CYB5R4

7.87E-3

Connective tissue development and function

Quantity of visceral fat

RETN

8.85E- 3

Carbohydrate metabolism

Binding of chondroitin sulfate

ADGRE2 (EMR2)

9.83E-3

  1. 51 additional enriched diseases and biological functions (statistically less significant) with p-values ranging between 1.0E-2 and 5.0E-2 are listed in Additional file 1: Table S7