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Table 4 Enriched diseases and biological functions (in the network of genes derived from GeneMANIA) with p-values ranging between 1.0E-4 and 1.0E-2 as identified by IPA based on Fisher’s exact test

From: Genotype-driven identification of a molecular network predictive of advanced coronary calcium in ClinSeq® and Framingham Heart Study cohorts

Category Disease or function Genes p-value
Connective tissue development and function Quantity of adipose tissue ARID5B, CYB5R4 3.58E-4
   RETN, TLR5  
Connective tissue development and function Differentiation of adipocytes ARID5B, EGLN1 8.82E-4
   NIPBL, RETN  
Cardiovascular disease Angiectasis of blood vessel EGLN1 9.87E-4
Cardiovascular system development and function Area of capillary vessel EGLN1 9.87E-4
Hematological system development and function Cell division of AIMP1 9.87E-4
  peripheral blood lymphocytes   
Cardiovascular disease, endocrine system disorders, Susceptibility to insulin RETN 9.87E-4
Metabolic disease resistance-related hypertension   
Cardiac necrosis, cell death and survival Cell death of heart tissue EGLN1 1.97E-3
Cellular movement Migration of connective tissue cells AIMP1, ARID5B 2.14E-3
   RETN  
Carbohydrate metabolism, cellular function Homeostasis of D-glucose CYB5R4, RETN 2.46E- 3
and maintenance   TLR5  
Nucleic acid metabolism Conversion of NAD+ NNT 2.96E- 3
Cardiovascular system development and function Tethering of endothelial cell lines FUT3 2.96E-3
Cellular compromise, inflammatory response Degranulation of beta islet cells CYB5R4 3.94E-3
Cardiovascular system development and function Density of blood vessel tissue AIMP1 3.94E-3
Endocrine system disorders, hematological disease Onset of hyperglycemia CYB5R4 3.94E-3
Metabolic disease    
Carbohydrate metabolism Tolerance of D-glucose CYB5R4 4.93E- 3
Cardiovascular system development and function Angiogenesis of heart EGLN1 5.91E-3
Cardiovascular system development and function Density of blood vessel AIMP1, EGLN1 5.96E-3
Immune cell trafficking, inflammatory response Adhesion of neutrophils ADGRE2 (EMR2) 7.52E-3
Hematological system development and function   TLR5  
Endocrine system development and function Insulin sensitivity of liver RETN 7.87E-3
Hepatic system development and function    
Nucleic acid metabolism Metabolism of NADPH CYB5R4 7.87E-3
Connective tissue development and function Quantity of visceral fat RETN 8.85E- 3
Carbohydrate metabolism Binding of chondroitin sulfate ADGRE2 (EMR2) 9.83E-3
  1. 51 additional enriched diseases and biological functions (statistically less significant) with p-values ranging between 1.0E-2 and 5.0E-2 are listed in Additional file 1: Table S7