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Table 3 List of abbreviated network node names for the EMT network and the ABA network

From: A framework to find the logic backbone of a biological network

Abbreviation

Full name (Gene name/ official name)

EMT network:

 

EMT

Epithelial to Mesenchymal Transition

TGF β

Transforming growth factor beta

PDGF

Platelet derived growth factor

SHH

Sonic Hedgehog

SNAI1

snail homolog 1 (Drosophila)

SNAI2

snail homolog 2 (Drosophila)

ZEB1

zinc finger E-box binding homeobox 1

ZEB2

zinc finger E-box binding homeobox 2

HEY1

hairy/enhancer-of-split related with YRPW motif 1

FOXC2

forkhead box C2 (MFH-1, mesenchyme forkhead 1)

TWIST1

twist basic helix-loop-helix transcription factor 1

ERK

mitogen-activated protein kinases 1 & 3

RAS

v-Ha-ras Harvey rat sarcoma viral oncogene

 

homolog

miR200

microRNA 200b

RKIP

phosphatidylethanolamine-binding protein 4;

 

RAF1 the inhibitory protein

MEK

mitogen-activated protein kinase kinases 1 & 2

CHD1L

chromodomain helicase DNA binding protein 1-like

IGF1

Insulin-like growth factor 1

EGF

epidermal growth factor

HGF

hepatocyte growth factor

FGF

fibroblast growth factor 2

Wnt

wingless-type MMTV integration site family,

 

member 1

NF κB

nuclear factor of kappa light polypeptide gene

 

enhancer in B-cells 1

βTrCP

beta-transducin repeat containing E3 ubiquitin

 

protein ligase

H1F1 α

hypoxia inducible factor 1, alpha subunit

 

(basic helix-loop-helix transcription factor)

FGFR

fibroblast growth factor receptor 1

PDGFR

platelet-derived growth factor receptor, alpha

 

& beta polypeptides

SOS/GRB2

son of sevenless homolog 1 (Drosophila) and

 

growth factor receptor-bound protein 2

GSK3 β

glycogen synthase kinase 3 beta

Dest_complex

Destruction complex

β-catenin_nuc

nuclear β-catenin (cadherin-associated protein)

β-catenin_memb

membrane-bound β-catenin

 

(cadherin-associated protein)

GLI

GLI family zinc finger 1 & 2

DSH

dishevelled, dsh homolog 1

SUFU

suppressor of fused homolog (Drosophila)

NOTCH_ic

NOTCH (Drosophila) Homolog 1

E-cadherin

cadherin 1, type 1, E-cadherin

TCF/LEF

a basic helix-loop-helix transcription factor &

 

lymphoid enhancer-binding factor 1

RAF

v-raf-1 murine leukemia viral oncogene homolog 1

ILK

integrin-linked kinase

AKT

v-akt murine thymoma viral oncogene

EGR1

early growth response 1

c-fos

FBJ murine osteosarcoma viral oncogene homolog

CsI

recombination signal binding protein for

 

immunoglobulin kappa J region

ABA network:

 

ABA

Abscisic acid

p H c

Increase of the cytosolic pH level

AtRAC1

small GTPase RAC1

ABI1

ABA (abscisic acid)-insensitive 1

ABI2

ABA (abscisic acid)-insensitive 2

\(Ca^{2+}_{c}\)

Cytosolic calcium

C a 2+ ATPase

Ca2+ ATPases and Ca2+/H+ antiporters responsible

 

for Ca2+ efflux from the cytosol

PLD δ

Phospholipase D δ

ROS

Reactive oxygen species

RBOH

NADPH oxidases AtRBOH D and F

PA

Phosphatidic acid

PI3P5K

Phosphatidylinositol 3-phosphate 5-kinase

PtdIns(3,5)P2

Phosphatidylinositol 3,5-bisphosphate

V-PPase

vacuolar proton pyrophosphatase

RCARs

Regulatory Components of ABA Receptor

OST1

protein kinase OPEN STOMATA 1

CaIM

C a 2+ influx across the plasma membrane

CIS

C a 2+ influx to the cytosol from intracellular stores

AnionEM

Anion efflux through the plasma membrane

K + Efflux

K + efflux through the plasma membrane

H 2 O Efflux

water efflux through the plasma membrane

MPK 9/12

Mitogen-activated protein kinases 9 and 12

CPK 3/21

Calcium-dependent protein kinases 3 and 21

SLAC1

Slow Anion Channel- associated 1