Fig. 3

Maximum minimum distance Latin hypercube designs of size n=8 (left panel) and n=20 (right panel). The blue points represent locations in rate or input parameter space where we would run the full systems biology model. These designs are both space filling and approximately orthogonal, both desirable features for fitting emulators. Note that the construction process of a Latin hypercube ensures that there is a blue point within each of the n subintervals of both inputs, ensuring excellent coverage