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Table 2 The input or rate parameter ranges that define the initial search region \(\mathcal {X}_{1}\) over which the history match is performed

From: Bayesian uncertainty analysis for complex systems biology models: emulation, global parameter searches and evaluation of gene functions

Input rate parameters

Minimum

Maximum

k 1

0.1

10

k 2/k 1a

0.02

2

k 2a /k 1a

0.28

28

k 2b

0.1

10

k 2c

1 × 10−6

1

k 3/k 1a

0.2

20

k 3a /k 1a

0.045

4.5

k 5/k 4

0.1

10

k 6

Control: 0 (pls mutant) or 0.3 (wildtype)

k 6a

0.002

2000

k 7

0.1

10

k 9/k 8

0.1

10

k 10a /k 10

166

1.66 × 104

k 11/k 10

166

1.66 × 105

k 12a /k 12

0.1

10

k 13/k 12

1

1000

k 15/k 14

2.83 × 10−4

0.283

k 16a /k 16

0.33

33.3

k 17/k 16

0.033

3.33

k 18

0.01

10

k 19/k 18a

0.01

10

k 1v a u x i n /k 1a

0.1

100

k 1v C K /k 18a

0.1

10

k 1v e t h /k 12

1

100

  1. Due to symmetries in the model at equilibrium, only ratios of certain parameters will be constrained, hence we choose to work directly with these ratios, as given in the left column. Note that k 6 is a control parameter used to define wildtype or pls mutant, and hence is not included in the parameter search