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Table 1 The ADME properties in silico of top 5 compounds via admetSAR Prediction

From: Network pharmacological mechanisms of Vernonia anthelmintica (L.) in the treatment of vitiligo: Isorhamnetin induction of melanogenesis via up-regulation of melanin-biosynthetic genes

Compounds Absorption Metabolism (CYP450 isoforms Inhibitor)
HIA Caco-2 CYP450 1A2 CYP450 2C9 CYP450 2D6 CYP450 2C19 CYP450 3A4 score
Isorhamnetin +0.9783 +0.8866 +0.9218 +0.7560 −0.6993 +0.8648 +0.7348 1.92963575
Kaempferide +0.9783 +0.8866 +0.9218 +0.7560 −0.6993 +0.8648 +0.7348 1.92963575
Isoliquiritigenin +0.9894 +0.8867 +0.935 +0.8949 −0.9231 +0.8994 +0.7959 1.92766477
Apigenin +0.9887 +0.8541 +0.9222 +0.7746 −0.9231 +0.7043 +0.9580 1.76820103
Liquiritigenin +0.9915 +0.7142 +0.8739 +0.9352 −0.8850 +0.8456 +0.5207 1.72194393