Table 1 Chemical reactions defining the two-state model. The rate constants are usually abbreviated to rates as they correspond to actual reactions rates when only one molecule of reactant is present. In the stochastic setting, these rates are in fact propensities, i.e. probabilities per unit of time
From: Inferring gene regulatory networks from single-cell data: a mechanistic approach
Reaction | Rate constant | Interpretation |
|---|---|---|
G→G ∗ | k on | gene activation |
G ∗→G | k off | gene inactivation |
G ∗→G ∗+M | s 0 | transcription |
M→M+P | s 1 | translation |
\(M \to \varnothing \) | d 0 | mRNA degradation |
\(P \to \varnothing \) | d 1 | protein degradation |