TY - JOUR AU - Sinha, Shriprakash PY - 2017 DA - 2017/12/04 TI - Hilbert-Schmidt and Sobol sensitivity indices for static and time series Wnt signaling measurements in colorectal cancer - part A JO - BMC Systems Biology SP - 120 VL - 11 IS - 1 AB - Ever since the accidental discovery of Wingless [Sharma R.P., Drosophila information service, 1973, 50, p 134], research in the field of Wnt signaling pathway has taken significant strides in wet lab experiments and various cancer clinical trials, augmented by recent developments in advanced computational modeling of the pathway. Information rich gene expression profiles reveal various aspects of the signaling pathway and help in studying different issues simultaneously. Hitherto, not many computational studies exist which incorporate the simultaneous study of these issues. SN - 1752-0509 UR - https://doi.org/10.1186/s12918-017-0488-z DO - 10.1186/s12918-017-0488-z ID - Sinha2017 ER -