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Fig. 4 | BMC Systems Biology

Fig. 4

From: Monitoring of nutrient limitation in growing E. coli: a mathematical model of a ppGpp-based biosensor

Fig. 4

Modelled kinetics of FA production during batch growth of E. coli cells. Kinetics of FA yields (a, in mg FA per 1 l of cell culture) and growth (b, in OD units) in cell cultures, expressing different amounts of thioesterase Tes. a, b. Solid, dashed, dotted and dashed-dotted lines correspond to the simulated control line 0 and lines 1, 2, 3 (indicated by numbers) with Tes activity of 0.08, 1.6, 19 and 110 mg/l/OD/min respectively. Data points are redrawn from [2] and correspond to lines 0 (red) and 1 (blue) (a) and lines 0, 2, 3 (b). c. Dependence of modelled FA yield of cell cultures after 24 h of growth on the levels of Tes activity. d. Intracellular kinetics of ppGpp (red) and Acyl-ACP (black) in the control line 0 and high Tes line 3, shown by solid and dashed-dotted lines respectively

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