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Table 1 Shadow prices for different metabolites in Wild-type and pfkA-mutant strains exposed to various substrate concentrations

From: Metabolic adaptation of two in silico mutants of Mycobacterium tuberculosis during infection

Metabolite G1 G2 G3 G4
WT ΔpfkA WT ΔpfkA WT ΔpfkA WT ΔpfkA
Oxygen −0.0273 −0,0273 −0.0278 −0,0365 −0.0278 −0,0305 −0.0215 −0,0232
Glucose −0.0601 −0.0601 −0.0500 0.0274 −0.0500 0.0122 −0.0484 0.0029
Glucose-6-P −0.0601 −0,0601 −0.0500 0,0274 −0.0500 0,0122 −0.0484 0,0029
Fructose-6-P −0.0601 −0,0601 −0.0500 0,0274 −0.0500 0,0122 −0.0484 0,0029
Ribose-5-P −0.0501 −0,0501 −0.0435 0,0061 −0.0435 −0,0031 −0.0421 −0,0087
Xylulose-5-P −0.0501 −0,0501 −0.0435 0,0061 −0.0435 −0,0031 −0.0421 −0,0087
Mannose-1-P −0.0601 −0,0601 −0.0500 0,0274 −0.0500 0,0122 −0.0484 0,0029
Mannose-6-P −0.0601 −0,0601 −0.0500 0,0274 −0.0500 0,0122 −0.0484 0,0029
Trehalose-6-P −0.1312 −0,1312 −0.1111 0,0426 −0.1111 0,0122 −0.1075 −0,0058
ATP −0.2223 −0,2223 −0.2186 −0,1948 −0.2186 −0,1956 −0.2007 −0,1804
Oxaloacetate −0.0191 −0,0191 −0.0194 −0,0274 −0.0194 −0,0214 −0.0134 −0,0145
Fumarate −0.0109 −0,0109 −0.0111 −0,0152 −0.0111 −0,0122 −0.0080 −0.0087
Succinate −0.0027 −0,0027 −0.0027 −0,0030 −0.0027 −0,0030 −0.0027 −0,0029
  1. G1, G2, G3 and G4, represent the phenotypic phases associated with definite nutrient conditions. Boldface shadow prices represent harmful intermediate metabolites for Mtb. Wild-type (WT); pfkA-mutant (ΔpfkA)