Metabolic adaptation of two in silico mutants of Mycobacterium tuberculosis during infection

BMC Systems Biology

Table 1 Shadow prices for different metabolites in Wild-type and pfkA-mutant strains exposed to various substrate concentrations

Metabolite	G1		G2		G3		G4
Metabolite	WT	ΔpfkA	WT	ΔpfkA	WT	ΔpfkA	WT	ΔpfkA
Oxygen	−0.0273	−0,0273	−0.0278	−0,0365	−0.0278	−0,0305	−0.0215	−0,0232
Glucose	−0.0601	−0.0601	−0.0500	0.0274	−0.0500	0.0122	−0.0484	0.0029
Glucose-6-P	−0.0601	−0,0601	−0.0500	0,0274	−0.0500	0,0122	−0.0484	0,0029
Fructose-6-P	−0.0601	−0,0601	−0.0500	0,0274	−0.0500	0,0122	−0.0484	0,0029
Ribose-5-P	−0.0501	−0,0501	−0.0435	0,0061	−0.0435	−0,0031	−0.0421	−0,0087
Xylulose-5-P	−0.0501	−0,0501	−0.0435	0,0061	−0.0435	−0,0031	−0.0421	−0,0087
Mannose-1-P	−0.0601	−0,0601	−0.0500	0,0274	−0.0500	0,0122	−0.0484	0,0029
Mannose-6-P	−0.0601	−0,0601	−0.0500	0,0274	−0.0500	0,0122	−0.0484	0,0029
Trehalose-6-P	−0.1312	−0,1312	−0.1111	0,0426	−0.1111	0,0122	−0.1075	−0,0058
ATP	−0.2223	−0,2223	−0.2186	−0,1948	−0.2186	−0,1956	−0.2007	−0,1804
Oxaloacetate	−0.0191	−0,0191	−0.0194	−0,0274	−0.0194	−0,0214	−0.0134	−0,0145
Fumarate	−0.0109	−0,0109	−0.0111	−0,0152	−0.0111	−0,0122	−0.0080	−0.0087
Succinate	−0.0027	−0,0027	−0.0027	−0,0030	−0.0027	−0,0030	−0.0027	−0,0029

G1, G2, G3 and G4, represent the phenotypic phases associated with definite nutrient conditions. Boldface shadow prices represent harmful intermediate metabolites for Mtb. Wild-type (WT); pfkA-mutant (ΔpfkA)

ISSN: 1752-0509