Table 2 Shadow prices for different metabolites in Wild-type and icl-mutant strains exposed to different substrate conditions
From: Metabolic adaptation of two in silico mutants of Mycobacterium tuberculosis during infection
Metabolite | F1 | F2 | F3 | F4 | F5 | |||||
|---|---|---|---|---|---|---|---|---|---|---|
WT | Δicl | WT | Δicl | WT | Δicl | WT | Δicl | WT | Δicl | |
Propionate | −0.0504 | −0.0495 | −0.0319 | −0.0319 | 0.0072 | 0.0072 | 0.0187 | 0.0187 | −0.0458 | −0.0458 |
Oxygen | 0.0101 | 0.0106 | 0.0053 | 0.0053 | −0.0096 | −0.0096 | −0.0213 | −0.0213 | 0.0109 | 0.0109 |
Propionyl-CoA | −0.0571 | −0.0566 | −0.0425 | −0.0425 | −0.0120 | −0.0120 | −0.0026 | −0.0026 | −0.0549 | −0.0549 |
Acetyl-CoA | −0.0336 | −0.0318 | −0.0266 | −0.0266 | −0.0120 | −0.0120 | −0.0133 | −0.0133 | −0.0329 | −0.0329 |
S-Methylmalonyl-CoA | −0.0604 | −0.0601 | −0.0478 | −0.0478 | −0.0217 | −0.0217 | −0.0133 | −0.0133 | −0.0567 | −0.0567 |
NADH | −0.0033 | −0.0071 | 0 | −0.0053 | 0 | 0 | 0 | 0.0053 | −0.0018 | −0.0055 |
Succinyl-CoA | −0.0604 | −0.0601 | −0.0478 | −0.0478 | −0.0217 | −0.0217 | −0.0133 | −0.0133 | −0.0567 | −0.0567 |
2-Methylcitrate | −0.1007 | −0.0990 | −0.0744 | −0.0744 | −0.0241 | −0.0241 | −0.0160 | −0.0160 | −0.0897 | −0.0897 |
2-Methyl-isocitrate | −0.1007 | −0.0990 | −0.0744 | −0.0744 | −0.0241 | −0.0241 | −0.0160 | −0.0160 | −0.0897 | −0.0897 |
Succinate | −0.0571 | −0.0566 | −0.0425 | −0.0425 | −0.0120 | −0.0120 | −0.0026 | −0.0026 | −0.0513 | −0.0513 |
Fumarate | −0.0504 | −0.0486 | −0.0372 | −0.0359 | −0.0120 | −0.0120 | −0.0080 | −0.0080 | −0.0439 | −0.0439 |
Glyoxylate | −0.0168 | −0.0177 | −0.0106 | −0.0106 | −0.0024 | 0 | −0.0133 | 0 | −0.0128 | −0.0128 |
Malate | −0.0504 | −0.0495 | −0.0372 | −0.0372 | −0.0121 | −0.0121 | −0.0080 | −0.0080 | −0.0439 | −0.0439 |
FADH2 | −0.0067 | −0.0071 | −0.0053 | −0.0053 | 0 | 0 | 0.0053 | 0.0053 | −0.0073 | −0.0073 |