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Table 2 Shadow prices for different metabolites in Wild-type and icl-mutant strains exposed to different substrate conditions

From: Metabolic adaptation of two in silico mutants of Mycobacterium tuberculosis during infection

Metabolite F1 F2 F3 F4 F5
WT Δicl WT Δicl WT Δicl WT Δicl WT Δicl
Propionate −0.0504 −0.0495 −0.0319 −0.0319 0.0072 0.0072 0.0187 0.0187 −0.0458 −0.0458
Oxygen 0.0101 0.0106 0.0053 0.0053 −0.0096 −0.0096 −0.0213 −0.0213 0.0109 0.0109
Propionyl-CoA −0.0571 −0.0566 −0.0425 −0.0425 −0.0120 −0.0120 −0.0026 −0.0026 −0.0549 −0.0549
Acetyl-CoA −0.0336 −0.0318 −0.0266 −0.0266 −0.0120 −0.0120 −0.0133 −0.0133 −0.0329 −0.0329
S-Methylmalonyl-CoA −0.0604 −0.0601 −0.0478 −0.0478 −0.0217 −0.0217 −0.0133 −0.0133 −0.0567 −0.0567
NADH −0.0033 −0.0071 0 −0.0053 0 0 0 0.0053 −0.0018 −0.0055
Succinyl-CoA −0.0604 −0.0601 −0.0478 −0.0478 −0.0217 −0.0217 −0.0133 −0.0133 −0.0567 −0.0567
2-Methylcitrate −0.1007 −0.0990 −0.0744 −0.0744 −0.0241 −0.0241 −0.0160 −0.0160 −0.0897 −0.0897
2-Methyl-isocitrate −0.1007 −0.0990 −0.0744 −0.0744 −0.0241 −0.0241 −0.0160 −0.0160 −0.0897 −0.0897
Succinate −0.0571 −0.0566 −0.0425 −0.0425 −0.0120 −0.0120 −0.0026 −0.0026 −0.0513 −0.0513
Fumarate −0.0504 −0.0486 −0.0372 −0.0359 −0.0120 −0.0120 −0.0080 −0.0080 −0.0439 −0.0439
Glyoxylate −0.0168 −0.0177 −0.0106 −0.0106 −0.0024 0 −0.0133 0 −0.0128 −0.0128
Malate −0.0504 −0.0495 −0.0372 −0.0372 −0.0121 −0.0121 −0.0080 −0.0080 −0.0439 −0.0439
FADH2 −0.0067 −0.0071 −0.0053 −0.0053 0 0 0.0053 0.0053 −0.0073 −0.0073
  1. F1, F2, F3, F4 and F5, represent the phenotypic phases associated with specific nutrient conditions. Boldface shadow prices represent harmful intermediate metabolites for Mtb. Wild-type (WT); pfkA-mutant (ΔpfkA)