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Fig. 2 | BMC Systems Biology

Fig. 2

From: Multiscale positive feedbacks contribute to unidirectional gastric disease progression induced by helicobacter pylori infection

Fig. 2

Dynamic change of Nf-κB and Shh following HP infection. a Temporal simulations of IkB proteins (black curve), Nf-κB(blue), and Nf-κB target genes (red) after induction of HP (at T = 5 h). b Temporal simulations of stomach acid (red), Sonic Hedgehog (Shh, black), and Interleukin-1 family of cytokines (IL-1, blue) after HP infection. c Temporal simulations of transforming growth factor beta (TGF-B, blue), BMMSC (red), and Shh (black) following HP infection. d The black curve shows the steady states of Shh as IL-1 level changes. TGF-β is set to be zero in this computation. The red curve shows the temporal changes of IL-1 and Shh from (b)

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BMC Systems Biology

ISSN: 1752-0509

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