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Fig. 4 | BMC Systems Biology

Fig. 4

From: Multiscale positive feedbacks contribute to unidirectional gastric disease progression induced by helicobacter pylori infection

Fig. 4

Enhanced cell cycle entry in response to HP infection. a and b Temporal simulations of Cdk (blue), Rb (black), CycD (green), p21 (red), and c-Myc (black dashed) in the absence of HP (a) and in the presence of HP (b). c Phase plane in the absence of HP infection. The balance curves of Cdk (blue), the balance curves of Rb (black), and separatrix (red) are computed. Also shown are stable attractors (black solid circles) and the unstable saddle point (black solid rectangle). The red temporal trajectory indicates the temporal change of Rb and Cdk from (a). d Phase plane analysis in the presence of HP infection. The notations are as in (c), and the red trajectory is taken from (b)

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