Fig. 8From: A computational study of the inhibition mechanisms of P-glycoprotein mediated paclitaxel efflux by kinase inhibitorsHypothetical improvement in NBD, SBD affinities and partition coefficient (PC) affect intracellular paclitaxel accumulation. Created by hypothetically improve affinity to NBD, SBD, and partition coefficient, separately, by 10 folds for nilotinib (left), imatinib (middle), and dasatinib (right). Initial concentrations of P-gp, paclitaxel and ATP were 10 μM, 3 μM, and 3 mM, respectivelyBack to article page