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Fig. 10 | BMC Systems Biology

Fig. 10

From: Designing synthetic networks in silico: a generalised evolutionary algorithm approach

Fig. 10

Multi-objective optimisation of oscillating networks for desired amplitudes and periods. a The obtained Pareto front of oscillating networks that have optimal amplitude and period properties (black line). Blue dots = optimal systems obtained when objectives have equal weight. Red dots = optimal systems when frequency objective is weighted to double that of other objectives. b Deterministic time-series simulations of all networks that lie along the Pareto front. c-e Schematics of a network with (c) high amplitude, low frequency; (d) median amplitude and frequency, and; (e) low amplitude, high frequency

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