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Fig. 11 | BMC Systems Biology

Fig. 11

From: Designing synthetic networks in silico: a generalised evolutionary algorithm approach

Fig. 11

Pareto front for incoherent feed-forward loops as in [33]. a Pareto front obtained by weighting different scoring functions. Grey dots = both objectives are equally weighted. Blue dots = sensitivity objective is weighted to double that of the precision objective. Red dots = precision objective is weighted to double that of the sensitivity objective. b Simulations from Pareto optimal networks. Blue line is simulation of network optimised for sensitivity to inputs. Red line is simulation from a network optimised for a precise return to pre-input concentration levels

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