Fig. 8
From: Designing synthetic networks in silico: a generalised evolutionary algorithm approach
Network optimisation of oscillating systems. a Network size is fixed to 4 nodes but connections can be evolved and TF proteins can function as either activators or inhibitors (blue bars) or both (red bars). The final networks are analysed to determine whether they possess limit cycle oscillations. b The evolution of the average score across generations from 250 EA runs. Blue line represents evolution of networks with single function TFs, red line represents networks with multi-function TFs. c Same as (a) except for full network evolution (network size is not fixed). d Evolution is performed for post-translational oscillators and networks are analysed for the presence of limit cycle oscillations