Fig. 2

Gene expression profiles of cell death executioner enzymes. a-c Gene expression profiles of caspases 3, 6, and 7 of all 2209 the cells. The cells are sorted according to the expression levels in descending order. d Combined gene expression (caspases 3, 6 and 7) and cell death probabilities of cells. The data are sorted according to the total gene expression levels. e-h Comparison of expression levels of caspases 3, 6, 7, as well as the total expression levels (caspases 3, 6 and 7) in β-cells. Overall, there are 270 β-cells. Among the cells, 171 of them are from healthy donors, and the rest from T2D donors. The expression of caspases 6, 7 and the total expression of the healthy group (represented with H in the figures) are all significantly lower than that of the T2D group. Only the expression levels of caspase 3 of the two groups do not show significant difference. The bold dark lines indicate the mean values of each group. The extent of differences is provided in the each figure. It is calculated by 1−MTCH/MTCT2D, where MTCH and MTCT2D are the mean values of the total expression levels of caspases 3, 6, and 7 of the healthy and T2D groups, respectively