Fig. 5

Comparison of node-based centralities between High-MI-incident/High-RD-incident group and the rest of genes in the signaling networks. a-e Results of node-based degree, betweenness, stress, closeness, and NuFBL, respectively, with respect to High-MI-incident group. In each subfigure, “The rest of genes” means non “High-MI-incident” genes. f-j Results of node-based degree, betweenness, stress, closeness, and NuFBL, respectively, with respect to High-RD-incident group. In each subfigure, “The rest of genes” means non “High-RD-incident” genes. For all subfigures, Y-Axis value and error bar represents the average and 95% confidence interval, respectively. Genes belonging to High-MI-incident and High-RD-incident group showed higher degree, node-based betweenness, stress, closeness, and the number of involved feedback loops than the rest of genes (All P-values < 0.05 except stress of STF in (c), closeness of HIV-1 in (d), and NuFBL of T-LGL in (j))