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Table 1 Results of GO analysis between High-MI-incident/High-RD-incident group and the rest of genes in T-LGL signalling network, with all P-values using Bonferroni test (see Additional file 1: Table S1 and S2 for the results of STF and HIV-1 signaling networks)

From: Investigation on changes of modularity and robustness by edge-removal mutations in signaling networks

Type of GO analysis GO term High-MI-incident (%) The rest of genes (%) P-value
Modularity change Non-membrane spanning protein tyrosine kinase activity 75.00 25.00 5.4E-6
Positive regulation of peptidase activity 57.62 48.01 3.4E-12
Positive regulation of adaptive immune response 75.00 25.00 34.0E-6
Regulation of immunoglobulin mediated immune response 75.00 25.00 2.9E-6
Phosphatase binding 85.71 14.29 72.0E-9
Protein phosphatase binding 83.33 16.67 260.0E-9
Cytokine receptor binding 64.29 35.71 2.1E-15
Death receptor binding 60.00 40.00 960.0E-12
  GO term High-RD-incident (%) The rest of genes (%) P-value
Robustness change Positive regulation of cysteine-type endopeptidase activity 63.62 42.41 24.0E-12
Positive regulation of peptidase activity 67.22 38.41 3.4E-12
Response to nicotine 60.00 40.00 200.0E-9
Regulation of adaptive immune response 83.33 16.67 540.0E-9
Positive regulation of apoptotic signaling pathway 67.22 38.41 13.0E-12
Regulation of NIK/NF-kappaB signaling 75.00 25.00 5.4E-6
Necroptotic signaling pathway 79.25 26.42 380.0E-9
Extrinsic apoptotic signaling pathway in absence of ligand 66.84 40.11 370.0E-12