Table 1 Results of GO analysis between High-MI-incident/High-RD-incident group and the rest of genes in T-LGL signalling network, with all P-values using Bonferroni test (see Additional file 1: Table S1 and S2 for the results of STF and HIV-1 signaling networks)
Type of GO analysis | GO term | High-MI-incident (%) | The rest of genes (%) | P-value |
|---|---|---|---|---|
Modularity change | Non-membrane spanning protein tyrosine kinase activity | 75.00 | 25.00 | 5.4E-6 |
Positive regulation of peptidase activity | 57.62 | 48.01 | 3.4E-12 | |
Positive regulation of adaptive immune response | 75.00 | 25.00 | 34.0E-6 | |
Regulation of immunoglobulin mediated immune response | 75.00 | 25.00 | 2.9E-6 | |
Phosphatase binding | 85.71 | 14.29 | 72.0E-9 | |
Protein phosphatase binding | 83.33 | 16.67 | 260.0E-9 | |
Cytokine receptor binding | 64.29 | 35.71 | 2.1E-15 | |
Death receptor binding | 60.00 | 40.00 | 960.0E-12 | |
| Â | GO term | High-RD-incident (%) | The rest of genes (%) | P-value |
Robustness change | Positive regulation of cysteine-type endopeptidase activity | 63.62 | 42.41 | 24.0E-12 |
Positive regulation of peptidase activity | 67.22 | 38.41 | 3.4E-12 | |
Response to nicotine | 60.00 | 40.00 | 200.0E-9 | |
Regulation of adaptive immune response | 83.33 | 16.67 | 540.0E-9 | |
Positive regulation of apoptotic signaling pathway | 67.22 | 38.41 | 13.0E-12 | |
Regulation of NIK/NF-kappaB signaling | 75.00 | 25.00 | 5.4E-6 | |
Necroptotic signaling pathway | 79.25 | 26.42 | 380.0E-9 | |
Extrinsic apoptotic signaling pathway in absence of ligand | 66.84 | 40.11 | 370.0E-12 |