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Fig. 5 | BMC Systems Biology

Fig. 5

From: Investigation and identification of functional post-translational modification sites associated with drug binding and protein-protein interactions

Fig. 5

A case study of the Thr145 phosphorylation site located in the interacting region of p21–PCNA complex (PDBID: 1AXC). The phosphorylation of the Thr145 residue of p21, which corresponds to the PCNA binding region (from residue 144 to 151), may inhibit the interaction between p21 and PCNA, resulting in PCNA binding with other DNA polymerase components [54]

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BMC Systems Biology

ISSN: 1752-0509

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