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Fig. 6 | BMC Systems Biology

Fig. 6

From: Investigation and identification of functional post-translational modification sites associated with drug binding and protein-protein interactions

Fig. 6

A case study of the Tyr127 phosphorylation site located in the interacting region of RhoGDI–Rac1 complex (PDBID: 1HH4). A disordered N-terminal domain of RhoGDI1 contains a tyrosine residue (Tyr27), which is localized to the docking interface. The phosphorylated Tyr127 has been reported to facilitate the dissociation of RhoA, Rac1, and cdc from RhoGDI1, making GTPases available for activation [57]

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