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Fig. 7 | BMC Systems Biology

Fig. 7

From: Investigation and identification of functional post-translational modification sites associated with drug binding and protein-protein interactions

Fig. 7

A case study of the phosphorylation sites located in the interacting region of the ternary complex of eIF4E-m7GpppA-4EBP1 peptide (PDBID: 1WKW). There are three substrate sites (Thr50, Tyr54 and Ser65) of phosphorylation within the binding region of the 4EBP1, which can regulate its interaction with eIF4E. These sites are reported to modulate the reversible binding of 4EBP1 with eIF4E, and hyper-phosphorylation at these sites decreases the strength of interaction between the two proteins [59]

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BMC Systems Biology

ISSN: 1752-0509

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