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Fig. 1 | BMC Systems Biology

Fig. 1

From: Constraint-based perturbation analysis with cluster Newton method: a case study of personalized parameter estimations with irinotecan whole-body physiologically based pharmacokinetic model

Fig. 1

WB-PBPK model for irinotecan and the metabolites. We constructed a WB-PBPK model of irinotecan and the metabolites including blood circulatory compartments and elimination compartments. Blood circulatory compartments include venous and artery blood, lung, heart, brain, muscle, adipose (Adipo.), skin, bone, kidney, spleen, pancreas (Panc.), stomach (Stomac.), small intestine (S.I.), large intestine (L.I.) and liver. Elimination compartments include three biliary transit, S.I., L.I., urine and feces. Structure of the WB-PBPK model in each compound is described (Fig. 2)

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BMC Systems Biology

ISSN: 1752-0509

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