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Fig. 5 | BMC Systems Biology

Fig. 5

From: Constraint-based perturbation analysis with cluster Newton method: a case study of personalized parameter estimations with irinotecan whole-body physiologically based pharmacokinetic model

Fig. 5

Distributions of parameters after the first CNM without constraints of Kp. The distributions of the optimized values of parameter #71 (renal clearance of CPT-11), #76 (liver clearance to bile of CPT-11), and #83 (liver metabolism from CPT-11 to APC) are described after the first CNM without constraints. The distributions of parameter #71, #76, and #83 are shown in (a), (b) and (c), respectively

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BMC Systems Biology

ISSN: 1752-0509

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