Fig. 6

Comparing distributions of estimated parameters by age group between CNM with and without constraints. We observe the distributions of optimized values of the estimated parameter #71 (renal clearance of CPT-11), #76 (liver clearance to bile of CPT-11), and #83 (liver metabolism from CPT-11 to APC) in different age groups (below 70 years, and 70 years and over) between by the CNM with and without constraints. The distributions of parameter #71, #76, and #83 are shown in (a), (b) and (c), respectively. The distributions of the estimated parameters by the CNM without constraints are not different between both age groups. On the other hand, the distributions of the estimated parameters by the CNM with constraints are considerably lower in 70 years and over than in below 70 years