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Table 1 Patient characteristics, dose of irinotecan and physiological parameters

From: Constraint-based perturbation analysis with cluster Newton method: a case study of personalized parameter estimations with irinotecan whole-body physiologically based pharmacokinetic model

  Patient 1 Patient 2 Patient 3 Patient 4 Patient 5 Patient 6 Patient 7
Sex Men Men Men Men Female Female Female
Age (years) 73 67 51 70 74 52 71
Height (cm) 171.6 169.4 182.3 182.5 170.6 169.4 188.6
Weight (kg) 109.1 89.1 78.6 98.2 88.0 52.7 83.2
BMI (kg/m2)a 37.1 31.0 23.7 29.5 30.2 18.4 23.4
Dose (μg/kg) 1000 1500 1700 1100 1400 2200 1400
Duration of infusion (min) 90 90 90 90 90 90 90
Volume (ml/kg)b
 Venous blood 12.8 15.6 18.7 14.9 12.3 20.4 14.0
 Artery blood 8.1 9.8 11.7 9.4 7.7 12.8 8.8
 Lung 11.6 14.1 16.9 13.5 11.9 19.7 13.5
 Heart 3.8 4.5 5.4 4.4 3.9 6.4 4.4
 Brain 13.8 16.9 19.2 15.4 15.4 25.7 16.3
 Muscle 290.8 352.7 422.4 338.4 238.4 396.0 271.9
 Adipose 469.0 360.6 240.0 391.2 516.4 210.8 452.6
 Skin 41.7 46.0 50.3 40.3 38.1 49.1 40.7
 Bone 106.3 128.9 154.4 123.7 107.3 178.2 122.3
 Kidney 3.9 4.8 5.7 4.6 4.7 7.9 5.4
 Spleen 2.2 2.7 3.2 2.5 2.6 4.3 2.9
 Pancreas 1.7 2.1 2.5 2.0 2.0 3.3 2.3
 Stomach 1.5 1.8 2.2 1.8 1.9 3.2 2.2
 Small Intestine 6.5 7.9 9.5 7.6 8.2 13.6 9.3
 Large Intestine 3.7 4.5 5.4 4.3 4.9 8.1 5.6
 Liver 21.2 25.7 30.8 24.7 22.4 37.2 25.5
Blood flow Rate (ml/min/kg)b
 Lung 54.9 66.6 79.8 63.9 64.7 107.5 73.8
 Heart 2.3 2.8 3.4 2.7 3.5 5.8 4.0
 Brain 7.0 8.5 10.2 8.2 8.3 13.8 9.5
 Muscle 9.9 12.1 14.4 11.6 7.8 13.0 8.9
 Adipose 2.9 3.5 4.2 3.4 5.9 9.8 6.7
 Skin 2.9 3.5 4.2 3.4 3.5 5.8 4.0
 Bone 2.9 3.5 4.2 3.4 3.5 5.8 4.0
 Kidney 11.9 14.5 17.3 13.9 13.2 21.9 15.0
 Spleen 1.8 2.1 2.5 2.0 2.1 3.5 2.4
 Pancreas 0.6 0.7 0.8 0.7 0.7 1.2 0.8
 Stomach 0.6 0.7 0.8 0.7 0.7 1.2 0.8
 Small Intestine 5.8 7.1 8.5 6.8 7.6 12.7 8.7
 Large Intestine 2.3 2.8 3.4 2.7 3.5 5.8 4.0
 Liver (Total) 14.9 18.1 21.7 17.3 18.7 31.1 21.4
 Liver (Artery) 3.8 4.6 5.5 4.4 4.5 7.5 5.1
  1. BMI, body-mass index
  2. aBMI is calculated as weight(kg)÷height(m)2
  3. bVolume and blood flow rate for each vessel and organ are calculated by using the work of Willmann et al. [15]