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Table 1 Patient characteristics, dose of irinotecan and physiological parameters

From: Constraint-based perturbation analysis with cluster Newton method: a case study of personalized parameter estimations with irinotecan whole-body physiologically based pharmacokinetic model

 

Patient 1

Patient 2

Patient 3

Patient 4

Patient 5

Patient 6

Patient 7

Sex

Men

Men

Men

Men

Female

Female

Female

Age (years)

73

67

51

70

74

52

71

Height (cm)

171.6

169.4

182.3

182.5

170.6

169.4

188.6

Weight (kg)

109.1

89.1

78.6

98.2

88.0

52.7

83.2

BMI (kg/m2)a

37.1

31.0

23.7

29.5

30.2

18.4

23.4

Dose (μg/kg)

1000

1500

1700

1100

1400

2200

1400

Duration of infusion (min)

90

90

90

90

90

90

90

Volume (ml/kg)b

 Venous blood

12.8

15.6

18.7

14.9

12.3

20.4

14.0

 Artery blood

8.1

9.8

11.7

9.4

7.7

12.8

8.8

 Lung

11.6

14.1

16.9

13.5

11.9

19.7

13.5

 Heart

3.8

4.5

5.4

4.4

3.9

6.4

4.4

 Brain

13.8

16.9

19.2

15.4

15.4

25.7

16.3

 Muscle

290.8

352.7

422.4

338.4

238.4

396.0

271.9

 Adipose

469.0

360.6

240.0

391.2

516.4

210.8

452.6

 Skin

41.7

46.0

50.3

40.3

38.1

49.1

40.7

 Bone

106.3

128.9

154.4

123.7

107.3

178.2

122.3

 Kidney

3.9

4.8

5.7

4.6

4.7

7.9

5.4

 Spleen

2.2

2.7

3.2

2.5

2.6

4.3

2.9

 Pancreas

1.7

2.1

2.5

2.0

2.0

3.3

2.3

 Stomach

1.5

1.8

2.2

1.8

1.9

3.2

2.2

 Small Intestine

6.5

7.9

9.5

7.6

8.2

13.6

9.3

 Large Intestine

3.7

4.5

5.4

4.3

4.9

8.1

5.6

 Liver

21.2

25.7

30.8

24.7

22.4

37.2

25.5

Blood flow Rate (ml/min/kg)b

 Lung

54.9

66.6

79.8

63.9

64.7

107.5

73.8

 Heart

2.3

2.8

3.4

2.7

3.5

5.8

4.0

 Brain

7.0

8.5

10.2

8.2

8.3

13.8

9.5

 Muscle

9.9

12.1

14.4

11.6

7.8

13.0

8.9

 Adipose

2.9

3.5

4.2

3.4

5.9

9.8

6.7

 Skin

2.9

3.5

4.2

3.4

3.5

5.8

4.0

 Bone

2.9

3.5

4.2

3.4

3.5

5.8

4.0

 Kidney

11.9

14.5

17.3

13.9

13.2

21.9

15.0

 Spleen

1.8

2.1

2.5

2.0

2.1

3.5

2.4

 Pancreas

0.6

0.7

0.8

0.7

0.7

1.2

0.8

 Stomach

0.6

0.7

0.8

0.7

0.7

1.2

0.8

 Small Intestine

5.8

7.1

8.5

6.8

7.6

12.7

8.7

 Large Intestine

2.3

2.8

3.4

2.7

3.5

5.8

4.0

 Liver (Total)

14.9

18.1

21.7

17.3

18.7

31.1

21.4

 Liver (Artery)

3.8

4.6

5.5

4.4

4.5

7.5

5.1

  1. BMI, body-mass index
  2. aBMI is calculated as weight(kg)÷height(m)2
  3. bVolume and blood flow rate for each vessel and organ are calculated by using the work of Willmann et al. [15]