Skip to main content

Table 2 Objective values for each patient

From: Constraint-based perturbation analysis with cluster Newton method: a case study of personalized parameter estimations with irinotecan whole-body physiologically based pharmacokinetic model

ID Parameters Patient 1 Patient 2 Patient 3 Patient 4 Patient 5 Patient 6 Patient 7
Urinary elimination ratio (%)
1 CPT-11 23.2 25.5 35.5 26.3 17.8 28.1 30.0
2 SN-38 0.4 0.5 0.7 0.5 0.3 0.5 0.6
3 SN-38G 3.1 3.4 4.8 3.6 2.4 3.8 4.0
4 NPC 0.1 0.2 0.2 0.2 0.1 0.2 0.2
5 APC 2.3 2.5 3.5 2.6 1.8 2.8 3.0
Fecal elimination ratio (%)
6 CPT-11 45.3 43.5 35.4 42.7 49.6 41.4 39.9
7 SN-38 + SN-38G 11.9 11.4 9.3 11.2 13.1 10.9 10.5
8 NPC 1.9 1.8 1.5 1.8 2.1 1.7 1.7
9 APC 11.6 11.2 9.1 11.0 12.7 10.6 10.2
Cmax (μg/ml)
10 CPT-11 1.53 1.53 1.53 1.53 1.53 1.53 1.53
11 SN-38 0.04 0.04 0.04 0.04 0.04 0.04 0.04
12 SN-38G 0.09 0.09 0.09 0.09 0.09 0.09 0.09
13 APC 0.19 0.19 0.19 0.19 0.19 0.19 0.19
  1. Cmax, maximum serum concentrations
  2. The total elimination ratio of urine and feces is normalized to the ratio of reported individual information. Ratios of metabolism from CPT-11 to its metabolites and Cmax of all compounds use average values in the report. Cmax of the metabolites are normalized to the amount of CPT-11