ID | Parameters | Unit | Min | Max |
|---|
1:5 | KpLung
| – | 0.1 | 10 |
6:10 | KpHeart
| – | 0.1 | 10 |
11:15 | KpBrain
| – | 0.1 | 10 |
16:20 | KpMuscle
| – | 0.1 | 10 |
21:25 | KpAdipose
| – | 0.1 | 10 |
26:30 | KpSkin
| – | 0.1 | 10 |
31:35 | KpBone
| – | 0.1 | 10 |
36:40 | KpKidney
| – | 0.1 | 10 |
41:45 | KpSpleen
| – | 0.1 | 10 |
46:50 | KpPancreas
| – | 0.1 | 10 |
51:55 | KpStomach
| – | 0.1 | 10 |
56:60 | KpSmall intestine
| – | 0.1 | 10 |
61:65 | KpLarge intestine
| – | 0.1 | 10 |
66:70 | KpLiver
| – | 0.1 | 10 |
71 | CLr(CPT-11) | ml/min/kg | 0.1 | 10 |
72:75 | CLr(metabolites) | ml/min/kg | 0.01 | 1 |
76:80 | CLbile
| ml/min/kg | 0.1 | 10 |
81 | CLCES,1
| ml/min/kg | 0.1 | 10 |
82 | CLCES,2
| ml/min/kg | 0.1 | 10 |
83 | CL3A4,1
| ml/min/kg | 0.1 | 10 |
84 | CL3A4,2
| ml/min/kg | 0.1 | 10 |
85 | CLUGT
| ml/min/kg | 0.1 | 10 |
86:90 | kbile
| /min | 0.001 | 0.1 |
91:95 | ka
| /min | 0.0001 | 0.01 |
96:100 | kL.I.
| /min | 0.0001 | 0.01 |
101:105 | kfeces
| /min | 0.0001 | 0.01 |
- KpLung, tissue-plasma partition coefficient of lungs; KpHeart, tissue-plasma partition coefficient of heart; KpBrain, tissue-plasma partition coefficient of brain; KpMuscle, tissue- plasma partition coefficient of muscles; KpAdipose, tissue-plasma partition coefficient of adipose; KpSkin, tissue-plasma partition coefficient of skins; KpBone, tissue-plasma partition coefficient of bones; KpKidney, tissue-plasma partition coefficient of kidneys; KpSpleen, tissue-plasma partition coefficient of spleen; KpPancreas, tissue-plasma partition coefficient of pancreas; KpStomach, tissue-plasma partition coefficient of stomach; KpSmall intestine, tissue-plasma partition coefficient of small intestine; KpLarge intestine, tissue-plasma partition coefficient of large intestine; KpLiver, tissue-plasma partition coefficient of liver; CLr (CPT-11), renal clearance of CPT-11; CLr (metabolites), renal clearance of SN-38, SN-38G, NPC or APC, respectively; CLbile, biliary clearance to transit compartment; CLCES,1, metabolic clearance of CPT-11 by CES2 to form SN-38; CLCES,2, metabolic clearance of NPC by CES2 to form SN-38; CL3A4,1, metabolic clearance of CPT-11 by CYP3A4 to form APC; CL3A4,2, metabolic clearance of CPT-11 by CYP3A4 to form NPC; CLUGT, metabolic clearance of SN-38 by UGT to form SN-38G; kbile, kinetic constant for the transit in bile compartments to small intestine; ka, absorption rate constant; kL.I., kinetic constants for the transit from small intestine to large intestine; kfeces, kinetic constant for the transit from large intestine to feces
