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Table 3 Drug related parameters to estimate

From: Constraint-based perturbation analysis with cluster Newton method: a case study of personalized parameter estimations with irinotecan whole-body physiologically based pharmacokinetic model

ID Parameters Unit Min Max
1:5 KpLung 0.1 10
6:10 KpHeart 0.1 10
11:15 KpBrain 0.1 10
16:20 KpMuscle 0.1 10
21:25 KpAdipose 0.1 10
26:30 KpSkin 0.1 10
31:35 KpBone 0.1 10
36:40 KpKidney 0.1 10
41:45 KpSpleen 0.1 10
46:50 KpPancreas 0.1 10
51:55 KpStomach 0.1 10
56:60 KpSmall intestine 0.1 10
61:65 KpLarge intestine 0.1 10
66:70 KpLiver 0.1 10
71 CLr(CPT-11) ml/min/kg 0.1 10
72:75 CLr(metabolites) ml/min/kg 0.01 1
76:80 CLbile ml/min/kg 0.1 10
81 CLCES,1 ml/min/kg 0.1 10
82 CLCES,2 ml/min/kg 0.1 10
83 CL3A4,1 ml/min/kg 0.1 10
84 CL3A4,2 ml/min/kg 0.1 10
85 CLUGT ml/min/kg 0.1 10
86:90 kbile /min 0.001 0.1
91:95 ka /min 0.0001 0.01
96:100 kL.I. /min 0.0001 0.01
101:105 kfeces /min 0.0001 0.01
  1. KpLung, tissue-plasma partition coefficient of lungs; KpHeart, tissue-plasma partition coefficient of heart; KpBrain, tissue-plasma partition coefficient of brain; KpMuscle, tissue- plasma partition coefficient of muscles; KpAdipose, tissue-plasma partition coefficient of adipose; KpSkin, tissue-plasma partition coefficient of skins; KpBone, tissue-plasma partition coefficient of bones; KpKidney, tissue-plasma partition coefficient of kidneys; KpSpleen, tissue-plasma partition coefficient of spleen; KpPancreas, tissue-plasma partition coefficient of pancreas; KpStomach, tissue-plasma partition coefficient of stomach; KpSmall intestine, tissue-plasma partition coefficient of small intestine; KpLarge intestine, tissue-plasma partition coefficient of large intestine; KpLiver, tissue-plasma partition coefficient of liver; CLr (CPT-11), renal clearance of CPT-11; CLr (metabolites), renal clearance of SN-38, SN-38G, NPC or APC, respectively; CLbile, biliary clearance to transit compartment; CLCES,1, metabolic clearance of CPT-11 by CES2 to form SN-38; CLCES,2, metabolic clearance of NPC by CES2 to form SN-38; CL3A4,1, metabolic clearance of CPT-11 by CYP3A4 to form APC; CL3A4,2, metabolic clearance of CPT-11 by CYP3A4 to form NPC; CLUGT, metabolic clearance of SN-38 by UGT to form SN-38G; kbile, kinetic constant for the transit in bile compartments to small intestine; ka, absorption rate constant; kL.I., kinetic constants for the transit from small intestine to large intestine; kfeces, kinetic constant for the transit from large intestine to feces