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Table 1 Hypothesis deletions for enhancing naringenin production in C. glutamicum and corresponding sorting criteria

From: OptPipe - a pipeline for optimizing metabolic engineering targets

Strain Growth rate min Nar max Nar Distance to WT p-value q-value Method
  (h −1) (mmol/gDCW/h) (mmol/gDCW/h) (mmol/gDCW/h)    
wild type 0.50 0 0     
Δ ackA Δ metY 0.32 0 0.50 400 0.0742 0.0779 OptKnock a
Δ pta Δ ilvA_ile 0.20 0 0.50 404 0.2432 0.1197  
Δ pta Δ metY 0.32 0 0.50 400 0.2342 0.1197  
Δ ackA Δ ilvA_ile 0.20 0 0.50 404 0.4139 0.1285  
Δ ackA Δ metY 0.32 0 0.50 400 0.3656 0.1285  
Δ sdhCAB Δ ddh 0.21 0 0.50 545 0.5443 0.1285 OptKnock
Δ mdh Δ pyc 0.23 0 0.49 39 0.5377 0.1285 screening
Δ pyc Δ zwf 0.13 0 0.50 565 0.8300 0.1285  
Δ pyc Δ opcA 0.13 0 0.50 565 0.8580 0.1285  
Δ pyc Δ gnd 0.13 0 0.50 565 0.8784 0.1285  
Δ pyc Δ rpe 0.16 0 0.50 441 0.7986 0.1285  
Δ pyc Δ tkt_1 0.15 0 0.50 532 0.8553 0.1285  
Δ pyc Δ tal 0.15 0 0.50 532 0.8940 0.1285  
Δ pyc Δ tkt_2 0.17 0 0.50 413 0.8340 0.1285  
Δ pyc Δ pmmB 0.19 0 0.17 47 0.7249 0.1285  
  1. aOptKnock result corresponding to the (single) obtained solution