TY - JOUR AU - Caccavale, Justin AU - Fiumara, David AU - Stapf, Michael AU - Sweitzer, Liedeke AU - Anderson, Hannah J. AU - Gorky, Jonathan AU - Dhurjati, Prasad AU - Galileo, Deni S. PY - 2017 DA - 2017/12/11 TI - A simple and accurate rule-based modeling framework for simulation of autocrine/paracrine stimulation of glioblastoma cell motility and proliferation by L1CAM in 2-D culture JO - BMC Systems Biology SP - 124 VL - 11 IS - 1 AB - Glioblastoma multiforme (GBM) is a devastating brain cancer for which there is no known cure. Its malignancy is due to rapid cell division along with high motility and invasiveness of cells into the brain tissue. Simple 2-dimensional laboratory assays (e.g., a scratch assay) commonly are used to measure the effects of various experimental perturbations, such as treatment with chemical inhibitors. Several mathematical models have been developed to aid the understanding of the motile behavior and proliferation of GBM cells. However, many are mathematically complicated, look at multiple interdependent phenomena, and/or use modeling software not freely available to the research community. These attributes make the adoption of models and simulations of even simple 2-dimensional cell behavior an uncommon practice by cancer cell biologists. SN - 1752-0509 UR - https://doi.org/10.1186/s12918-017-0516-z DO - 10.1186/s12918-017-0516-z ID - Caccavale2017 ER -