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Fig. 1 | BMC Systems Biology

Fig. 1

From: A simple and accurate rule-based modeling framework for simulation of autocrine/paracrine stimulation of glioblastoma cell motility and proliferation by L1CAM in 2-D culture

Fig. 1

Connectivity map of the signaling pathways leading to motility and proliferation in a GBM cell. A GBM cell is shown as the large green oval. 1. GBM cell expresses L1CAM cell surface adhesion protein. 2. Cell releases the L1CAM ectodomain (L1ecto) after proteolysis from the cell surface. 3. L1ecto autocrine/paracrine binds to integrin (a) and FGFR (b) receptors to initiate intracellular signaling pathways (4.), which converge via FAK signaling (c). 5. Resulting cellular behavior is manifested as increased cell proliferation and motility

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