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Fig. 6 | BMC Systems Biology

Fig. 6

From: A simple and accurate rule-based modeling framework for simulation of autocrine/paracrine stimulation of glioblastoma cell motility and proliferation by L1CAM in 2-D culture

Fig. 6

Simulation with cellular adhesion on. “cellular-adhesion” and “show-L?” were turned on before the simulation was run. a. Simulation was stopped after only 10 min had elapsed on the Time indicator box. Note the intercellular connections (lines) between the blue cells behind the scratch line. Green cells are not bound by adhesive bonds and are beginning to release L1ecto (yellow dots). b. At the end of the simulation, many cells have migrated beyond the scratch line into open space and are releasing L1ecto. Cells behind the scratch line remain interconnected by adhesive bonds. Note that 3 green cells have migrated back into the confluent monolayer (white arrows). Such cells often reestablish adhesive bonds with neighboring cells

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