Fig. 3
From: Estimating drivers of cell state transitions using gene regulatory network models
Strong reproducibility in top differential transcription factor involvement found in case-control COPD studies. ECLIPSE and COPDGene profiled gene expression in whole-blood and PBMC while the gene expression data in LGRC and LT-CDNM were assayed in lung tissue. a Results for studies with gene expression data obtained from the same-tissue. Both the blood based (left) and lung tissue studies (right) demonstrate very high Spearman correlation of differential involvement. b Despite using data from different sources we found agreement between studies of different tissues. c Venn diagram depicting the top 20 transcription factors found in each study. The union of all top 20 lists contains 36 transcription factors