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Table 1 Pharmacokinetic parameters for three models

From: Linking physiologically-based pharmacokinetic and genome-scale metabolic networks to understand estradiol biology

   In vivo PBPK PBPK-LiverODE PBPK-GSMN
i.v. – 0.3 mg AUC 10.2 ± 1.18 10.4 ± 0.23 6.1 ± 0.17 5.9 ± 0.56
Oral – 2 mg Tmax 3.8 ± 0.4 2.5 ± 0.34 3.5 ± 0.38 2.4 ± 0.18
Cmax 0.44 ± 0.24 0.34 ± 0.19 0.35 ± 0.24 0.32 ± 0.23
AUC 10.3 ± 1.18 8.9 ± 0.19 9.2 ± 0.13 8.1 ± 0.04
Oral – 4 mg Tmax 3.4 ± 0.6 3.1 ± 0.31 3.2 ± 0.35 2.3 ± 0.26
Cmax 0.63 ± 0.3 0.67 ± 0.25 0.71 ± 0.26 0.65 ± 0.21
AUC 13.4 ± 3.47 17.3 ± 0.38 17.4 ± 0.24 16.2 ± 0.09
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