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Table 1 Pharmacokinetic parameters for three models

From: Linking physiologically-based pharmacokinetic and genome-scale metabolic networks to understand estradiol biology

  

In vivo

PBPK

PBPK-LiverODE

PBPK-GSMN

i.v. – 0.3 mg

AUC

10.2 ± 1.18

10.4 ± 0.23

6.1 ± 0.17

5.9 ± 0.56

Oral – 2 mg

Tmax

3.8 ± 0.4

2.5 ± 0.34

3.5 ± 0.38

2.4 ± 0.18

Cmax

0.44 ± 0.24

0.34 ± 0.19

0.35 ± 0.24

0.32 ± 0.23

AUC

10.3 ± 1.18

8.9 ± 0.19

9.2 ± 0.13

8.1 ± 0.04

Oral – 4 mg

Tmax

3.4 ± 0.6

3.1 ± 0.31

3.2 ± 0.35

2.3 ± 0.26

Cmax

0.63 ± 0.3

0.67 ± 0.25

0.71 ± 0.26

0.65 ± 0.21

AUC

13.4 ± 3.47

17.3 ± 0.38

17.4 ± 0.24

16.2 ± 0.09

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BMC Systems Biology

ISSN: 1752-0509

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