TY - CHAP AU - Cheema, A. K. AU - Fiandaca, M. S. AU - Mapstone, M. AU - Federoff, H. J. ED - Sturmberg, P. J. PY - 2016 DA - 2016// TI - Systems biology: unravelling molecular complexity in health and disease BT - The Value of Systems and Complexity Sciences for Healthcare PB - Springer international publishing CY - Cham UR - https://doi.org/10.1007/978-3-319-26221-5_2 DO - 10.1007/978-3-319-26221-5_2 ID - Cheema2016 ER - TY - JOUR AU - Gorban, A. N. AU - Smirnova, E. V. AU - Tyukina, T. A. PY - 2010 DA - 2010// TI - Correlations, risk and crisis: from physiology to finance JO - Physica A VL - 389 UR - https://doi.org/10.1016/j.physa.2010.03.035 DO - 10.1016/j.physa.2010.03.035 ID - Gorban2010 ER - TY - JOUR AU - Federoff, H. J. AU - Gostin, L. O. PY - 2009 DA - 2009// TI - Evolving from reductionism to holism: is there a future for systems medicine? JO - JAMA VL - 302 UR - https://doi.org/10.1001/jama.2009.1264 DO - 10.1001/jama.2009.1264 ID - Federoff2009 ER - TY - JOUR AU - Jack, C. R. AU - Knopman, D. S. AU - Jagust, W. J. AU - Petersen, R. C. AU - Weiner, M. W. AU - Aisen, P. S. AU - Shaw, L. M. AU - Vemuri, P. AU - Wiste, H. J. AU - Weigand, S. D. PY - 2013 DA - 2013// TI - Tracking pathophysiological processes in Alzheimer's disease: an updated hypothetical model of dynamic biomarkers JO - Lancet Neurol VL - 12 UR - https://doi.org/10.1016/S1474-4422(12)70291-0 DO - 10.1016/S1474-4422(12)70291-0 ID - Jack2013 ER - TY - JOUR AU - Hirsch, G. AU - Homer, J. AU - Evans, E. AU - Zielinski, A. PY - 2010 DA - 2010// TI - A system dynamics model for planning cardiovascular disease interventions JO - Am J Public Health VL - 100 UR - https://doi.org/10.2105/AJPH.2009.159434 DO - 10.2105/AJPH.2009.159434 ID - Hirsch2010 ER - TY - JOUR AU - Arbeev, K. G. AU - Ukraintseva, S. V. AU - Akushevich, I. AU - Kulminski, A. M. AU - Arbeeva, L. S. AU - Akushevich, L. AU - Culminskaya, I. V. AU - Yashin, A. I. PY - 2011 DA - 2011// TI - Age trajectories of physiological indices in relation to healthy life course JO - Mech Ageing Dev VL - 132 UR - https://doi.org/10.1016/j.mad.2011.01.001 DO - 10.1016/j.mad.2011.01.001 ID - Arbeev2011 ER - TY - JOUR AU - Lunney, J. R. AU - Lynn, J. AU - Foley, D. J. AU - Lipson, S. AU - Guralnik, J. M. PY - 2003 DA - 2003// TI - Patterns of functional decline at the end of life JO - JAMA VL - 289 UR - https://doi.org/10.1001/jama.289.18.2387 DO - 10.1001/jama.289.18.2387 ID - Lunney2003 ER - TY - JOUR AU - Hieronymi, A. PY - 2013 DA - 2013// TI - Understanding systems science: a visual and integrative approach JO - Syst Res Behav Sci VL - 30 UR - https://doi.org/10.1002/sres.2215 DO - 10.1002/sres.2215 ID - Hieronymi2013 ER - TY - CHAP AU - Clark, T. C. AU - Black, L. I. AU - Stussman, B. J. AU - Barnes, P. M. AU - Nahin, R. L. PY - 2015 DA - 2015// TI - Trends in the use of complementary health approaches among adults: United States, 2002–2012 BT - National health statistics reports; no. 79 PB - National Center for Health Statistics CY - Hyattsville, MD ID - Clark2015 ER - TY - JOUR AU - Weil, A. PY - 2000 DA - 2000// TI - The significance of integrative medicine for the future of medical education JO - Am J Med VL - 108 UR - https://doi.org/10.1016/S0002-9343(00)00334-X DO - 10.1016/S0002-9343(00)00334-X ID - Weil2000 ER - TY - JOUR AU - Jones, D. PY - 2008 DA - 2008// TI - A look at the Institute for Functional Medicine with David Jones, MD. (interviewed by mark a Hyman) JO - Altern Ther Health Med VL - 14 ID - Jones2008 ER - TY - JOUR AU - Chopra, A. AU - Doiphode, V. V. PY - 2002 DA - 2002// TI - Ayurvedic medicine - Core concept, therapeutic principles, and current relevance JO - Med Clin N Am VL - 86 UR - https://doi.org/10.1016/S0025-7125(03)00073-7 DO - 10.1016/S0025-7125(03)00073-7 ID - Chopra2002 ER - TY - BOOK AU - Hough, H. J. AU - Dower, C. AU - O’Neil, E. H. PY - 2001 DA - 2001// TI - Profile of a Profession: Naturopathic Practice PB - Centre for the Health Professions; UCSF CY - San Francisco, CA ID - Hough2001 ER - TY - STD TI - Kaptchuk TJ: The web that has no weaver: understanding Chinese medicine, 2nd edn: McGraw Hill; 2000. ID - ref14 ER - TY - JOUR AU - Goldstein, M. S. AU - Sutherland, C. AU - Jaffe, D. T. AU - Wilson, J. PY - 1988 DA - 1988// TI - Holistic physicians and family practitioners: similarities, differences and implications for health policy JO - Soc Sci Med VL - 26 UR - https://doi.org/10.1016/0277-9536(88)90178-5 DO - 10.1016/0277-9536(88)90178-5 ID - Goldstein1988 ER - TY - JOUR AU - Rakel, D. P. AU - Rindfleisch, A. PY - 2005 DA - 2005// TI - Inflammation: nutritional, botanical, and mind-body influences JO - South Med J VL - 98 UR - https://doi.org/10.1097/01.SMJ.0000154775.16761.A9 DO - 10.1097/01.SMJ.0000154775.16761.A9 ID - Rakel2005 ER - TY - STD TI - Fischer T, Brothers KB, Erdmann P, Langanke M. Clinical decision-making and secondary findings in systems medicine. Bmc Med Ethics. 2016;17 ID - ref17 ER - TY - JOUR AU - Maier, D. PY - 2017 DA - 2017// TI - Applying systems medicine in the clinic JO - Curr Opin Syst Biol VL - 3 UR - https://doi.org/10.1016/j.coisb.2017.04.014 DO - 10.1016/j.coisb.2017.04.014 ID - Maier2017 ER - TY - JOUR AU - Parikshak, N. N. AU - Gandal, M. J. AU - Geschwind, D. H. PY - 2015 DA - 2015// TI - Systems biology and gene networks in neurodevelopmental and neurodegenerative disorders JO - Nat Rev Genet VL - 16 UR - https://doi.org/10.1038/nrg3934 DO - 10.1038/nrg3934 ID - Parikshak2015 ER - TY - JOUR AU - Bard, J. PY - 2013 DA - 2013// TI - Systems biology - the broader perspective JO - Cell VL - 2 UR - https://doi.org/10.3390/cells2020414 DO - 10.3390/cells2020414 ID - Bard2013 ER - TY - JOUR AU - Hood, L. AU - Friend, S. H. PY - 2011 DA - 2011// TI - Predictive, personalized, preventive, participatory (P4) cancer medicine JO - Nat Rev Clin Oncol VL - 8 UR - https://doi.org/10.1038/nrclinonc.2010.227 DO - 10.1038/nrclinonc.2010.227 ID - Hood2011 ER - TY - JOUR AU - Price, N. D. AU - Magis, A. T. AU - Earls, J. C. AU - Glusman, G. AU - Levy, R. AU - Lausted, C. AU - McDonald, D. T. AU - Kusebauch, U. AU - Moss, C. L. AU - Zhou, Y. PY - 2017 DA - 2017// TI - A wellness study of 108 individuals using personal, dense, dynamic data clouds JO - Nat Biotechnol VL - 35 UR - https://doi.org/10.1038/nbt.3870 DO - 10.1038/nbt.3870 ID - Price2017 ER - TY - JOUR AU - Berwick, D. M. AU - Nolan, T. W. AU - Whittington, J. PY - 2008 DA - 2008// TI - The triple aim: care, health, and cost JO - Health Aff VL - 27 UR - https://doi.org/10.1377/hlthaff.27.3.759 DO - 10.1377/hlthaff.27.3.759 ID - Berwick2008 ER - TY - STD TI - WHO: World Health Organization. Dementia: a public health priority. Geneva: World Health Organization; 2012. ISBN 978–92–4-156445-8. ID - ref24 ER - TY - JOUR AU - McKhann, G. M. AU - Knopman, D. S. AU - Chertkow, H. AU - Hyman, B. T. AU - Jack, C. R. AU - Kawas, C. H. AU - Klunk, W. E. AU - Koroshetz, W. J. AU - Manly, J. J. AU - Mayeux, R. PY - 2011 DA - 2011// TI - The diagnosis of dementia due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease JO - Alzheimers Dement VL - 7 UR - https://doi.org/10.1016/j.jalz.2011.03.005 DO - 10.1016/j.jalz.2011.03.005 ID - McKhann2011 ER - TY - JOUR AU - Thies, W. AU - Bleiler, L. AU - Alzheimer’s, A. PY - 2013 DA - 2013// TI - 2013 Alzheimer’s disease facts and figures JO - Alzheimers Dement VL - 9 UR - https://doi.org/10.1016/j.jalz.2013.02.003 DO - 10.1016/j.jalz.2013.02.003 ID - Thies2013 ER - TY - JOUR AU - Hebert, L. E. AU - Weuve, J. AU - Scherr, P. A. AU - Evans, D. A. PY - 2013 DA - 2013// TI - Alzheimer disease in the United States (2010-2050) estimated using the 2010 census JO - Neurology VL - 80 UR - https://doi.org/10.1212/WNL.0b013e31828726f5 DO - 10.1212/WNL.0b013e31828726f5 ID - Hebert2013 ER - TY - JOUR AU - Albert, M. S. AU - DeKosky, S. T. AU - Dickson, D. AU - Dubois, B. AU - Feldman, H. H. AU - Fox, N. C. AU - Gamst, A. AU - Holtzman, D. M. AU - Jagust, W. J. AU - Petersen, R. C. PY - 2011 DA - 2011// TI - The diagnosis of mild cognitive impairment due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease JO - Alzheimers Dement VL - 7 UR - https://doi.org/10.1016/j.jalz.2011.03.008 DO - 10.1016/j.jalz.2011.03.008 ID - Albert2011 ER - TY - JOUR AU - Sperling, R. A. AU - Aisen, P. S. AU - Beckett, L. A. AU - Bennett, D. A. AU - Craft, S. AU - Fagan, A. M. AU - Iwatsubo, T. AU - Jack, C. R. AU - Kaye, J. AU - Montine, T. J. PY - 2011 DA - 2011// TI - Toward defining the preclinical stages of Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease JO - Alzheimers Dement VL - 7 UR - https://doi.org/10.1016/j.jalz.2011.03.003 DO - 10.1016/j.jalz.2011.03.003 ID - Sperling2011 ER - TY - JOUR AU - Braak, H. AU - Braak, E. PY - 1991 DA - 1991// TI - Demonstration of amyloid deposits and neurofibrillary changes in whole brain sections JO - Brain Pathol VL - 1 UR - https://doi.org/10.1111/j.1750-3639.1991.tb00661.x DO - 10.1111/j.1750-3639.1991.tb00661.x ID - Braak1991 ER - TY - JOUR AU - Braak, H. AU - Braak, E. PY - 1991 DA - 1991// TI - Neuropathological stageing of Alzheimer-related changes JO - Acta Neuropathol VL - 82 UR - https://doi.org/10.1007/BF00308809 DO - 10.1007/BF00308809 ID - Braak1991 ER - TY - JOUR AU - Ringman, J. M. AU - Liang, L. J. AU - Zhou, Y. AU - Vangala, S. AU - Teng, E. AU - Kremen, S. AU - Wharton, D. AU - Goate, A. AU - Marcus, D. S. AU - Farlow, M. PY - 2015 DA - 2015// TI - Early behavioural changes in familial Alzheimer's disease in the dominantly inherited Alzheimer network JO - Brain VL - 138 UR - https://doi.org/10.1093/brain/awv004 DO - 10.1093/brain/awv004 ID - Ringman2015 ER - TY - JOUR AU - Panegyres, P. K. AU - Chen, H. Y. PY - 2013 DA - 2013// TI - Differences between early and late onset Alzheimer's disease JO - Am J Neurodegener dis VL - 2 ID - Panegyres2013 ER - TY - JOUR AU - Price, D. L. AU - Sisodia, S. S. PY - 1998 DA - 1998// TI - Mutant genes in familial Alzheimer's disease and transgenic models JO - Annu Rev Neurosci VL - 21 UR - https://doi.org/10.1146/annurev.neuro.21.1.479 DO - 10.1146/annurev.neuro.21.1.479 ID - Price1998 ER - TY - JOUR AU - Oddo, S. AU - Caccamo, A. AU - Shepherd, J. D. AU - Murphy, M. P. AU - Golde, T. E. AU - Kayed, R. AU - Metherate, R. AU - Mattson, M. P. AU - Akbari, Y. AU - LaFerla, F. M. PY - 2003 DA - 2003// TI - Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction JO - Neuron VL - 39 UR - https://doi.org/10.1016/S0896-6273(03)00434-3 DO - 10.1016/S0896-6273(03)00434-3 ID - Oddo2003 ER - TY - JOUR AU - Cramer, P. E. AU - Cirrito, J. R. AU - Wesson, D. W. AU - Lee, C. Y. AU - Karlo, J. C. AU - Zinn, A. E. AU - Casali, B. T. AU - Restivo, J. L. AU - Goebel, W. D. AU - James, M. J. PY - 2012 DA - 2012// TI - ApoE-directed therapeutics rapidly clear beta-amyloid and reverse deficits in AD mouse models JO - Science VL - 335 UR - https://doi.org/10.1126/science.1217697 DO - 10.1126/science.1217697 ID - Cramer2012 ER - TY - JOUR AU - Mullane, K. AU - Williams, M. PY - 2013 DA - 2013// TI - Alzheimer's therapeutics: continued clinical failures question the validity of the amyloid hypothesis-but what lies beyond? JO - Biochem Pharmacol VL - 85 UR - https://doi.org/10.1016/j.bcp.2012.11.014 DO - 10.1016/j.bcp.2012.11.014 ID - Mullane2013 ER - TY - JOUR AU - Pavlopoulos, G. A. AU - Secrier, M. AU - Moschopoulos, C. N. AU - Soldatos, T. G. AU - Kossida, S. AU - Aerts, J. AU - Schneider, R. AU - Bagos, P. G. PY - 2011 DA - 2011// TI - Using graph theory to analyze biological networks JO - BioData mining VL - 4 UR - https://doi.org/10.1186/1756-0381-4-10 DO - 10.1186/1756-0381-4-10 ID - Pavlopoulos2011 ER - TY - JOUR AU - Rovelet-Lecrux, A. AU - Hannequin, D. AU - Raux, G. AU - Le Meur, N. AU - Laquerriere, A. AU - Vital, A. AU - Dumanchin, C. AU - Feuillette, S. AU - Brice, A. AU - Vercelletto, M. PY - 2006 DA - 2006// TI - APP locus duplication causes autosomal dominant early-onset Alzheimer disease with cerebral amyloid angiopathy JO - Nat Genet VL - 38 UR - https://doi.org/10.1038/ng1718 DO - 10.1038/ng1718 ID - Rovelet-Lecrux2006 ER - TY - JOUR AU - Jonsson, T. AU - Atwal, J. K. AU - Steinberg, S. AU - Snaedal, J. AU - Jonsson, P. V. AU - Bjornsson, S. AU - Stefansson, H. AU - Sulem, P. AU - Gudbjartsson, D. AU - Maloney, J. PY - 2012 DA - 2012// TI - A mutation in APP protects against Alzheimer's disease and age-related cognitive decline JO - Nature VL - 488 UR - https://doi.org/10.1038/nature11283 DO - 10.1038/nature11283 ID - Jonsson2012 ER - TY - STD TI - Corder EH, Saunders AM, Risch NJ, Strittmatter WJ, Schmechel DE, Gaskell PC, Jr., Rimmler JB, Locke PA, Conneally PM, Schmader KE et al: Protective effect of apolipoprotein E type 2 allele for late onset Alzheimer disease. Nat Genet 1994, 7(2):180–184. ID - ref41 ER - TY - JOUR AU - Cacace, R. AU - Sleegers, K. AU - Van Broeckhoven, C. PY - 2016 DA - 2016// TI - Molecular genetics of early-onset Alzheimer's disease revisited JO - Alzheimers Dement VL - 12 UR - https://doi.org/10.1016/j.jalz.2016.01.012 DO - 10.1016/j.jalz.2016.01.012 ID - Cacace2016 ER - TY - JOUR AU - Corneveaux, J. J. AU - Myers, A. J. AU - Allen, A. N. AU - Pruzin, J. J. AU - Ramirez, M. AU - Engel, A. AU - Nalls, M. A. AU - Chen, K. AU - Lee, W. AU - Chewning, K. PY - 2010 DA - 2010// TI - Association of CR1, CLU and PICALM with Alzheimer's disease in a cohort of clinically characterized and neuropathologically verified individuals JO - Hum Mol Genet VL - 19 UR - https://doi.org/10.1093/hmg/ddq221 DO - 10.1093/hmg/ddq221 ID - Corneveaux2010 ER - TY - JOUR AU - Giri, M. AU - Zhang, M. AU - Lu, Y. PY - 2016 DA - 2016// TI - Genes associated with Alzheimer's disease: an overview and current status JO - Clin Interv Aging VL - 11 UR - https://doi.org/10.2147/CIA.S105769 DO - 10.2147/CIA.S105769 ID - Giri2016 ER - TY - JOUR AU - Karch, C. M. AU - Cruchaga, C. AU - Goate, A. M. PY - 2014 DA - 2014// TI - Alzheimer's disease genetics: from the bench to the clinic JO - Neuron VL - 83 UR - https://doi.org/10.1016/j.neuron.2014.05.041 DO - 10.1016/j.neuron.2014.05.041 ID - Karch2014 ER - TY - JOUR AU - Lambert, J. C. AU - Ibrahim-Verbaas, C. A. AU - Harold, D. AU - Naj, A. C. AU - Sims, R. AU - Bellenguez, C. AU - DeStafano, A. L. AU - Bis, J. C. AU - Beecham, G. W. AU - Grenier-Boley, B. PY - 2013 DA - 2013// TI - Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease JO - Nat Genet VL - 45 UR - https://doi.org/10.1038/ng.2802 DO - 10.1038/ng.2802 ID - Lambert2013 ER - TY - JOUR AU - Beecham, G. W. AU - Hamilton, K. AU - Naj, A. C. AU - Martin, E. R. AU - Huentelman, M. AU - Myers, A. J. AU - Corneveaux, J. J. AU - Hardy, J. AU - Vonsattel, J. P. AU - Younkin, S. G. PY - 2014 DA - 2014// TI - Genome-wide association meta-analysis of neuropathologic features of Alzheimer's disease and related dementias JO - PLoS Genet VL - 10 UR - https://doi.org/10.1371/journal.pgen.1004606 DO - 10.1371/journal.pgen.1004606 ID - Beecham2014 ER - TY - JOUR AU - Ridge, P. G. AU - Mukherjee, S. AU - Crane, P. K. AU - Kauwe, J. S. PY - 2013 DA - 2013// TI - Alzheimer's disease genetics C: Alzheimer's disease: analyzing the missing heritability JO - PLoS One VL - 8 UR - https://doi.org/10.1371/journal.pone.0079771 DO - 10.1371/journal.pone.0079771 ID - Ridge2013 ER - TY - JOUR AU - Singleton, A. AU - Hardy, J. PY - 2011 DA - 2011// TI - A generalizable hypothesis for the genetic architecture of disease: pleomorphic risk loci JO - Hum Mol Genet VL - 20 UR - https://doi.org/10.1093/hmg/ddr358 DO - 10.1093/hmg/ddr358 ID - Singleton2011 ER - TY - JOUR AU - Kaprio, J. PY - 2012 DA - 2012// TI - Twins and the mystery of missing heritability: the contribution of gene-environment interactions JO - J Intern Med VL - 272 UR - https://doi.org/10.1111/j.1365-2796.2012.02587.x DO - 10.1111/j.1365-2796.2012.02587.x ID - Kaprio2012 ER - TY - JOUR AU - Zuk, O. AU - Hechter, E. AU - Sunyaev, S. R. AU - Lander, E. S. PY - 2012 DA - 2012// TI - The mystery of missing heritability: genetic interactions create phantom heritability JO - Proc Natl Acad Sci U S A VL - 109 UR - https://doi.org/10.1073/pnas.1119675109 DO - 10.1073/pnas.1119675109 ID - Zuk2012 ER - TY - JOUR AU - Hohman, T. J. AU - Bush, W. S. AU - Jiang, L. AU - Brown-Gentry, K. D. AU - Torstenson, E. S. AU - Dudek, S. M. AU - Mukherjee, S. AU - Naj, A. AU - Kunkle, B. W. AU - Ritchie, M. D. PY - 2016 DA - 2016// TI - Discovery of gene-gene interactions across multiple independent data sets of late onset Alzheimer disease from the Alzheimer disease genetics consortium JO - Neurobiol Aging VL - 38 UR - https://doi.org/10.1016/j.neurobiolaging.2015.10.031 DO - 10.1016/j.neurobiolaging.2015.10.031 ID - Hohman2016 ER - TY - JOUR AU - Zhang, B. AU - Gaiteri, C. AU - Bodea, L. G. AU - Wang, Z. AU - McElwee, J. AU - Podtelezhnikov, A. A. AU - Zhang, C. AU - Xie, T. AU - Tran, L. AU - Dobrin, R. PY - 2013 DA - 2013// TI - Integrated systems approach identifies genetic nodes and networks in late-onset Alzheimer's disease JO - Cell VL - 153 UR - https://doi.org/10.1016/j.cell.2013.03.030 DO - 10.1016/j.cell.2013.03.030 ID - Zhang2013 ER - TY - JOUR AU - Miller, J. A. AU - Oldham, M. C. AU - Geschwind, D. H. PY - 2008 DA - 2008// TI - A systems level analysis of transcriptional changes in Alzheimer's disease and normal aging JO - J Neurosci VL - 28 UR - https://doi.org/10.1523/JNEUROSCI.4098-07.2008 DO - 10.1523/JNEUROSCI.4098-07.2008 ID - Miller2008 ER - TY - JOUR AU - Young, J. H. AU - Marcotte, E. M. PY - 2017 DA - 2017// TI - Predictability of genetic interactions from functional gene modules JO - G3 (Bethesda) VL - 7 UR - https://doi.org/10.1534/g3.116.035915 DO - 10.1534/g3.116.035915 ID - Young2017 ER - TY - JOUR AU - Ray, M. AU - Ruan, J. AU - Zhang, W. PY - 2008 DA - 2008// TI - Variations in the transcriptome of Alzheimer's disease reveal molecular networks involved in cardiovascular diseases JO - Genome Biol VL - 9 UR - https://doi.org/10.1186/gb-2008-9-10-r148 DO - 10.1186/gb-2008-9-10-r148 ID - Ray2008 ER - TY - JOUR AU - Matthews, P. M. AU - Filippini, N. AU - Douaud, G. PY - 2013 DA - 2013// TI - Brain structural and functional connectivity and the progression of neuropathology in Alzheimer’s disease JO - J Alzheimers Dis VL - 33 ID - Matthews2013 ER - TY - JOUR AU - Hibar, D. P. AU - Adams, H. H. AU - Jahanshad, N. AU - Chauhan, G. AU - Stein, J. L. AU - Hofer, E. AU - Renteria, M. E. AU - Bis, J. C. AU - Arias-Vasquez, A. AU - Ikram, M. K. PY - 2017 DA - 2017// TI - Novel genetic loci associated with hippocampal volume JO - Nat Commun VL - 8 UR - https://doi.org/10.1038/ncomms13624 DO - 10.1038/ncomms13624 ID - Hibar2017 ER - TY - JOUR AU - Moon, S. W. AU - Dinov, I. D. AU - Kim, J. AU - Zamanyan, A. AU - Hobel, S. AU - Thompson, P. M. AU - Toga, A. W. PY - 2015 DA - 2015// TI - Structural neuroimaging genetics interactions in Alzheimer's disease JO - J Alzheimers Dis VL - 48 UR - https://doi.org/10.3233/JAD-150335 DO - 10.3233/JAD-150335 ID - Moon2015 ER - TY - JOUR AU - Desikan, R. S. AU - Fan, C. C. AU - Wang, Y. AU - Schork, A. J. AU - Cabral, H. J. AU - Cupples, L. A. AU - Thompson, W. K. AU - Besser, L. AU - Kukull, W. A. AU - Holland, D. PY - 2017 DA - 2017// TI - Genetic assessment of age-associated Alzheimer disease risk: development and validation of a polygenic hazard score JO - PLoS Med VL - 14 UR - https://doi.org/10.1371/journal.pmed.1002258 DO - 10.1371/journal.pmed.1002258 ID - Desikan2017 ER - TY - JOUR AU - Baker, M. S. AU - Phillips, S. T. PY - 2011 DA - 2011// TI - A two-component small molecule system for activity-based detection and signal amplification: application to the visual detection of threshold levels of Pd(II) JO - J Am Chem Soc VL - 133 UR - https://doi.org/10.1021/ja108347d DO - 10.1021/ja108347d ID - Baker2011 ER - TY - STD TI - Han X, D MH, McKeel DW, Jr., Kelley J, Morris JC: Substantial sulfatide deficiency and ceramide elevation in very early Alzheimer's disease: potential role in disease pathogenesis. J Neurochem 2002, 82(4):809–818. ID - ref62 ER - TY - JOUR AU - Mapstone, M. AU - Cheema, A. K. AU - Fiandaca, M. S. AU - Zhong, X. AU - Mhyre, T. R. AU - MacArthur, L. H. AU - Hall, W. J. AU - Fisher, S. G. AU - Peterson, D. R. AU - Haley, J. M. PY - 2014 DA - 2014// TI - Plasma phospholipids identify antecedent memory impairment in older adults JO - Nat Med VL - 20 UR - https://doi.org/10.1038/nm.3466 DO - 10.1038/nm.3466 ID - Mapstone2014 ER - TY - JOUR AU - Fiandaca, M. S. AU - Zhong, X. AU - Cheema, A. K. AU - Orquiza, M. H. AU - Chidambaram, S. AU - Tan, M. T. AU - Gresenz, C. R. AU - FitzGerald, K. T. AU - Nalls, M. A. AU - Singleton, A. B. PY - 2015 DA - 2015// TI - Plasma 24-metabolite panel predicts preclinical transition to clinical stages of Alzheimer's disease JO - Front Neurol VL - 6 UR - https://doi.org/10.3389/fneur.2015.00237 DO - 10.3389/fneur.2015.00237 ID - Fiandaca2015 ER - TY - JOUR AU - Mapstone, M. AU - Lin, F. AU - Nalls, M. A. AU - Cheema, A. K. AU - Singleton, A. B. AU - Fiandaca, M. S. AU - Federoff, H. J. PY - 2017 DA - 2017// TI - What success can teach us about failure: the plasma metabolome of older adults with superior memory and lessons for Alzheimer's disease JO - Neurobiol Aging VL - 51 UR - https://doi.org/10.1016/j.neurobiolaging.2016.11.007 DO - 10.1016/j.neurobiolaging.2016.11.007 ID - Mapstone2017 ER - TY - JOUR AU - Hardy, J. PY - 2017 DA - 2017// TI - Membrane damage is at the core of Alzheimer's disease JO - Lancet Neurol VL - 16 UR - https://doi.org/10.1016/S1474-4422(17)30091-1 DO - 10.1016/S1474-4422(17)30091-1 ID - Hardy2017 ER - TY - JOUR AU - Fabelo, N. AU - Martin, V. AU - Marin, R. AU - Moreno, D. AU - Ferrer, I. AU - Diaz, M. PY - 2014 DA - 2014// TI - Altered lipid composition in cortical lipid rafts occurs at early stages of sporadic Alzheimer's disease and facilitates APP/BACE1 interactions JO - Neurobiol Aging VL - 35 UR - https://doi.org/10.1016/j.neurobiolaging.2014.02.005 DO - 10.1016/j.neurobiolaging.2014.02.005 ID - Fabelo2014 ER - TY - JOUR AU - Nasaruddin, M. L. AU - Holscher, C. AU - Kehoe, P. AU - Graham, S. F. AU - Green, B. D. PY - 2016 DA - 2016// TI - Wide-ranging alterations in the brain fatty acid complement of subjects with late Alzheimer's disease as detected by GC-MS JO - Am J Transl Res VL - 8 ID - Nasaruddin2016 ER - TY - JOUR AU - Klavins, K. AU - Koal, T. AU - Dallmann, G. AU - Marksteiner, J. AU - Kemmler, G. AU - Humpel, C. PY - 2015 DA - 2015// TI - The ratio of phosphatidylcholines to lysophosphatidylcholines in plasma differentiates healthy controls from patients with Alzheimer's disease and mild cognitive impairment JO - Alzheimers Dement (Amst) VL - 1 ID - Klavins2015 ER - TY - JOUR AU - Whiley, L. AU - Sen, A. AU - Heaton, J. AU - Proitsi, P. AU - Garcia-Gomez, D. AU - Leung, R. AU - Smith, N. AU - Thambisetty, M. AU - Kloszewska, I. AU - Mecocci, P. PY - 2014 DA - 2014// TI - Evidence of altered phosphatidylcholine metabolism in Alzheimer's disease JO - Neurobiol Aging VL - 35 UR - https://doi.org/10.1016/j.neurobiolaging.2013.08.001 DO - 10.1016/j.neurobiolaging.2013.08.001 ID - Whiley2014 ER - TY - JOUR AU - Katada, S. AU - Imhof, A. AU - Sassone-Corsi, P. PY - 2012 DA - 2012// TI - Connecting threads: epigenetics and metabolism JO - Cell VL - 148 UR - https://doi.org/10.1016/j.cell.2012.01.001 DO - 10.1016/j.cell.2012.01.001 ID - Katada2012 ER - TY - BOOK AU - Allis, C. D. AU - Caparros, M. -. L. AU - Jenuwein, T. AU - Reinberg, D. PY - 2015 DA - 2015// TI - Epigenetics, second edition. Edn PB - CSH Press, Cold Spring Harbor Laboratory Press CY - Cold Spring Harbor, New York ID - Allis2015 ER - TY - STD TI - Qazi TJ, Quan Z, Mir A, Qing H. Epigenetics in Alzheimer's disease: perspective of DNA methylation. Mol Neurobiol. 2017; ID - ref73 ER - TY - JOUR AU - Watson, C. T. AU - Roussos, P. AU - Garg, P. AU - Ho, D. J. AU - Azam, N. AU - Katsel, P. L. AU - Haroutunian, V. AU - Sharp, A. J. AU - Genome-wide, D. N. A. PY - 2016 DA - 2016// TI - Methylation profiling in the superior temporal gyrus reveals epigenetic signatures associated with Alzheimer's disease JO - Genome Med VL - 8 UR - https://doi.org/10.1186/s13073-015-0258-8 DO - 10.1186/s13073-015-0258-8 ID - Watson2016 ER - TY - JOUR AU - Scarmeas, N. AU - Stern, Y. AU - Tang, M. X. AU - Mayeux, R. AU - Luchsinger, J. A. PY - 2006 DA - 2006// TI - Mediterranean diet and risk for Alzheimer's disease JO - Ann Neurol VL - 59 UR - https://doi.org/10.1002/ana.20854 DO - 10.1002/ana.20854 ID - Scarmeas2006 ER - TY - JOUR AU - Farina, N. AU - Rusted, J. AU - Tabet, N. PY - 2014 DA - 2014// TI - The effect of exercise interventions on cognitive outcome in Alzheimer's disease: a systematic review JO - Int Psychogeriatr VL - 26 ID - Farina2014 ER - TY - JOUR AU - Radak, Z. AU - Hart, N. AU - Sarga, L. AU - Koltai, E. AU - Atalay, M. AU - Ohno, H. AU - Boldogh, I. PY - 2010 DA - 2010// TI - Exercise plays a preventive role against Alzheimer's disease JO - J Alzheimers Dis VL - 20 UR - https://doi.org/10.3233/JAD-2010-091531 DO - 10.3233/JAD-2010-091531 ID - Radak2010 ER - TY - JOUR AU - Kivipelto, M. AU - Solomon, A. AU - Ahtiluoto, S. AU - Ngandu, T. AU - Lehtisalo, J. AU - Antikainen, R. AU - Backman, L. AU - Hanninen, T. AU - Jula, A. AU - Laatikainen, T. PY - 2013 DA - 2013// TI - The Finnish geriatric intervention study to prevent cognitive impairment and disability (FINGER): study design and progress JO - Alzheimers Dement VL - 9 UR - https://doi.org/10.1016/j.jalz.2012.09.012 DO - 10.1016/j.jalz.2012.09.012 ID - Kivipelto2013 ER - TY - JOUR AU - Soininen, H. AU - Visser, P. J. AU - Kivipelto, M. AU - Hartmann, T. PY - 2016 DA - 2016// TI - A clinical trial investigating the effects of fortasyn connect (souvenaid) in prodromal Alzheimer's disease: results of the LipiDiDiet study JO - Neurobiol Aging VL - 39 UR - https://doi.org/10.1016/j.neurobiolaging.2016.01.102 DO - 10.1016/j.neurobiolaging.2016.01.102 ID - Soininen2016 ER - TY - JOUR AU - Tolppanen, A. M. AU - Solomon, A. AU - Kulmala, J. AU - Kareholt, I. AU - Ngandu, T. AU - Rusanen, M. AU - Laatikainen, T. AU - Soininen, H. AU - Kivipelto, M. PY - 2015 DA - 2015// TI - Leisure-time physical activity from mid- to late life, body mass index, and risk of dementia JO - Alzheimers Dement VL - 11 UR - https://doi.org/10.1016/j.jalz.2014.01.008 DO - 10.1016/j.jalz.2014.01.008 ID - Tolppanen2015 ER - TY - JOUR AU - Mendoza, J. AU - Pevet, P. AU - Challet, E. PY - 2008 DA - 2008// TI - High-fat feeding alters the clock synchronization to light JO - J Physiol VL - 586 UR - https://doi.org/10.1113/jphysiol.2008.159566 DO - 10.1113/jphysiol.2008.159566 ID - Mendoza2008 ER - TY - JOUR AU - Eckel-Mahan, K. L. AU - Patel, V. R. AU - de Mateo, S. AU - Orozco-Solis, R. AU - Ceglia, N. J. AU - Sahar, S. AU - Dilag-Penilla, S. A. AU - Dyar, K. A. AU - Baldi, P. AU - Sassone-Corsi, P. PY - 2013 DA - 2013// TI - Reprogramming of the circadian clock by nutritional challenge JO - Cell VL - 155 UR - https://doi.org/10.1016/j.cell.2013.11.034 DO - 10.1016/j.cell.2013.11.034 ID - Eckel-Mahan2013 ER - TY - JOUR AU - Voigt, R. M. AU - Forsyth, C. B. AU - Green, S. J. AU - Mutlu, E. AU - Engen, P. AU - Vitaterna, M. H. AU - Turek, F. W. AU - Keshavarzian, A. PY - 2014 DA - 2014// TI - Circadian disorganization alters intestinal microbiota JO - PLoS One VL - 9 UR - https://doi.org/10.1371/journal.pone.0097500 DO - 10.1371/journal.pone.0097500 ID - Voigt2014 ER - TY - JOUR AU - Murakami, M. AU - Tognini, P. AU - Liu, Y. AU - Eckel-Mahan, K. L. AU - Baldi, P. AU - Sassone-Corsi, P. PY - 2016 DA - 2016// TI - Gut microbiota directs PPARgamma-driven reprogramming of the liver circadian clock by nutritional challenge JO - EMBO Rep VL - 17 UR - https://doi.org/10.15252/embr.201642463 DO - 10.15252/embr.201642463 ID - Murakami2016 ER - TY - JOUR AU - Koivisto, H. AU - Grimm, M. O. AU - Rothhaar, T. L. AU - Berkecz, R. AU - Lutjohann, D. D. AU - Giniatullina, R. AU - Takalo, M. AU - Miettinen, P. O. AU - Lahtinen, H. M. AU - Giniatullin, R. PY - 2014 DA - 2014// TI - Special lipid-based diets alleviate cognitive deficits in the APPswe/PS1dE9 transgenic mouse model of Alzheimer's disease independent of brain amyloid deposition JO - J Nutr Biochem VL - 25 UR - https://doi.org/10.1016/j.jnutbio.2013.09.015 DO - 10.1016/j.jnutbio.2013.09.015 ID - Koivisto2014 ER - TY - JOUR AU - Hartmann, T. AU - van Wijk, N. AU - Wurtman, R. J. AU - Olde Rikkert, M. G. AU - Sijben, J. W. AU - Soininen, H. AU - Vellas, B. AU - Scheltens, P. PY - 2014 DA - 2014// TI - A nutritional approach to ameliorate altered phospholipid metabolism in Alzheimer's disease JO - J Alzheimers Dis VL - 41 ID - Hartmann2014 ER - TY - JOUR AU - van Wijk, N. AU - Broersen, L. M. AU - de Wilde, M. C. AU - Hageman, R. J. AU - Groenendijk, M. AU - Sijben, J. W. AU - Kamphuis, P. J. PY - 2014 DA - 2014// TI - Targeting synaptic dysfunction in Alzheimer's disease by administering a specific nutrient combination JO - J Alzheimers Dis VL - 38 ID - van Wijk2014 ER - TY - JOUR AU - Lamb, J. AU - Crawford, E. D. AU - Peck, D. AU - Modell, J. W. AU - Blat, I. C. AU - Wrobel, M. J. AU - Lerner, J. AU - Brunet, J. P. AU - Subramanian, A. AU - Ross, K. N. PY - 2006 DA - 2006// TI - The connectivity map: using gene-expression signatures to connect small molecules, genes, and disease JO - Science VL - 313 UR - https://doi.org/10.1126/science.1132939 DO - 10.1126/science.1132939 ID - Lamb2006 ER - TY - STD TI - Connectivity Map (CMAP) - Broad Institute [https://www.broadinstitute.org/connectivity-map-cmap]. UR - https://www.broadinstitute.org/connectivity-map-cmap ID - ref89 ER - TY - JOUR AU - Lamb, J. PY - 2007 DA - 2007// TI - The connectivity map: a new tool for biomedical research JO - Nat Rev Cancer VL - 7 UR - https://doi.org/10.1038/nrc2044 DO - 10.1038/nrc2044 ID - Lamb2007 ER - TY - JOUR AU - McArt, D. G. AU - Dunne, P. D. AU - Blayney, J. K. AU - Salto-Tellez, M. AU - Van Schaeybroeck, S. AU - Hamilton, P. W. AU - Zhang, S. D. PY - 2013 DA - 2013// TI - Connectivity mapping for candidate therapeutics identification using next generation sequencing RNA-Seq data JO - PLoS One VL - 8 UR - https://doi.org/10.1371/journal.pone.0066902 DO - 10.1371/journal.pone.0066902 ID - McArt2013 ER - TY - STD TI - Wen Q, O'Reilly P, Dunne PD, Lawler M, Van Schaeybroeck S, Salto-Tellez M, Hamilton P, Zhang SD: Connectivity mapping using a combined gene signature from multiple colorectal cancer datasets identified candidate drugs including existing chemotherapies. BMC systems biology 2015, 9 Suppl 5:S4. ID - ref92 ER - TY - JOUR AU - O'Reilly, P. G. AU - Wen, Q. AU - Bankhead, P. AU - Dunne, P. D. AU - McArt, D. G. AU - McPherson, S. AU - Hamilton, P. W. AU - Mills, K. I. AU - Zhang, S. D. PY - 2016 DA - 2016// TI - QUADrATiC: scalable gene expression connectivity mapping for repurposing FDA-approved therapeutics JO - BMC bioinformatics VL - 17 UR - https://doi.org/10.1186/s12859-016-1062-1 DO - 10.1186/s12859-016-1062-1 ID - O'Reilly2016 ER - TY - JOUR AU - Stary, H. C. PY - 2000 DA - 2000// TI - Natural history and histological classification of atherosclerotic lesions: an update JO - Arterioscler Thromb Vasc Biol VL - 20 UR - https://doi.org/10.1161/01.ATV.20.5.1177 DO - 10.1161/01.ATV.20.5.1177 ID - Stary2000 ER - TY - STD TI - Louridas GE, Lourida KG. Conceptual foundations of systems biology explaining complex cardiac diseases. Healthcare (Basel). 2017;5(1) ID - ref95 ER - TY - JOUR AU - Bjorkegren, J. L. AU - Kovacic, J. C. AU - Dudley, J. T. AU - Schadt, E. E. PY - 2015 DA - 2015// TI - Genome-wide significant loci: how important are they? Systems genetics to understand heritability of coronary artery disease and other common complex disorders JO - J Am Coll Cardiol VL - 65 UR - https://doi.org/10.1016/j.jacc.2014.12.033 DO - 10.1016/j.jacc.2014.12.033 ID - Bjorkegren2015 ER - TY - CHAP AU - Xu, J. Q. AU - Murphy, S. L. AU - Kochanek, K. D. AU - Arias, E. ED - NCfH, S. PY - 2016 DA - 2016// BT - Mortality in the United States, 2015 PB - NCHS data brief, no 267 CY - Hyattsville, MD ID - Xu2016 ER - TY - JOUR AU - Baigent, C. AU - Keech, A. AU - Kearney, P. M. AU - Blackwell, L. AU - Buck, G. AU - Pollicino, C. AU - Kirby, A. AU - Sourjina, T. AU - Peto, R. AU - Collins, R. PY - 2005 DA - 2005// TI - Efficacy and safety of cholesterol-lowering treatment: prospective meta-analysis of data from 90,056 participants in 14 randomised trials of statins JO - Lancet VL - 366 UR - https://doi.org/10.1016/S0140-6736(05)67394-1 DO - 10.1016/S0140-6736(05)67394-1 ID - Baigent2005 ER - TY - STD TI - Chapman J. Beyond LDL-cholesterol reduction: the way ahead in managing dyslipidaemia. Eur Heart J. 2005;(Suppl F):F56–62. ID - ref99 ER - TY - JOUR AU - McCarthy, M. I. AU - Abecasis, G. R. AU - Cardon, L. R. AU - Goldstein, D. B. AU - Little, J. AU - Ioannidis, J. P. AU - Hirschhorn, J. N. PY - 2008 DA - 2008// TI - Genome-wide association studies for complex traits: consensus, uncertainty and challenges JO - Nat Rev Genet VL - 9 UR - https://doi.org/10.1038/nrg2344 DO - 10.1038/nrg2344 ID - McCarthy2008 ER - TY - JOUR AU - Lander, E. S. AU - Schork, N. J. PY - 1994 DA - 1994// TI - Genetic dissection of complex traits JO - Science VL - 265 UR - https://doi.org/10.1126/science.8091226 DO - 10.1126/science.8091226 ID - Lander1994 ER - TY - JOUR AU - Consortium, C. A. D. AU - Deloukas, P. AU - Kanoni, S. AU - Willenborg, C. AU - Farrall, M. AU - Assimes, T. L. AU - Thompson, J. R. AU - Ingelsson, E. AU - Saleheen, D. AU - Erdmann, J. PY - 2013 DA - 2013// TI - Large-scale association analysis identifies new risk loci for coronary artery disease JO - Nat Genet VL - 45 UR - https://doi.org/10.1038/ng.2480 DO - 10.1038/ng.2480 ID - Consortium2013 ER - TY - JOUR AU - Nikpay, M. AU - Goel, A. AU - Won, H. H. AU - Hall, L. M. AU - Willenborg, C. AU - Kanoni, S. AU - Saleheen, D. AU - Kyriakou, T. AU - Nelson, C. P. AU - Hopewell, J. C. PY - 2015 DA - 2015// TI - A comprehensive 1,000 genomes-based genome-wide association meta-analysis of coronary artery disease JO - Nat Genet VL - 47 UR - https://doi.org/10.1038/ng.3396 DO - 10.1038/ng.3396 ID - Nikpay2015 ER - TY - JOUR AU - Schunkert, H. AU - Konig, I. R. AU - Kathiresan, S. AU - Reilly, M. P. AU - Assimes, T. L. AU - Holm, H. AU - Preuss, M. AU - Stewart, A. F. AU - Barbalic, M. AU - Gieger, C. PY - 2011 DA - 2011// TI - Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease JO - Nat Genet VL - 43 UR - https://doi.org/10.1038/ng.784 DO - 10.1038/ng.784 ID - Schunkert2011 ER - TY - JOUR AU - Makinen, V. P. AU - Civelek, M. AU - Meng, Q. AU - Zhang, B. AU - Zhu, J. AU - Levian, C. AU - Huan, T. AU - Segre, A. V. AU - Ghosh, S. AU - Vivar, J. PY - 2014 DA - 2014// TI - Integrative genomics reveals novel molecular pathways and gene networks for coronary artery disease JO - PLoS Genet VL - 10 UR - https://doi.org/10.1371/journal.pgen.1004502 DO - 10.1371/journal.pgen.1004502 ID - Makinen2014 ER - TY - JOUR AU - Ghosh, S. AU - Vivar, J. AU - Nelson, C. P. AU - Willenborg, C. AU - Segre, A. V. AU - Makinen, V. P. AU - Nikpay, M. AU - Erdmann, J. AU - Blankenberg, S. AU - O'Donnell, C. PY - 2015 DA - 2015// TI - Systems genetics analysis of genome-wide association study reveals novel associations between key biological processes and coronary artery disease JO - Arterioscler Thromb Vasc Biol VL - 35 UR - https://doi.org/10.1161/ATVBAHA.115.305513 DO - 10.1161/ATVBAHA.115.305513 ID - Ghosh2015 ER - TY - JOUR AU - Wray, N. R. AU - Goddard, M. E. AU - Visscher, P. M. PY - 2007 DA - 2007// TI - Prediction of individual genetic risk to disease from genome-wide association studies JO - Genome Res VL - 17 UR - https://doi.org/10.1101/gr.6665407 DO - 10.1101/gr.6665407 ID - Wray2007 ER - TY - JOUR AU - Smith, J. A. AU - Ware, E. B. AU - Middha, P. AU - Beacher, L. AU - Kardia, S. L. PY - 2015 DA - 2015// TI - Current applications of genetic risk scores to cardiovascular outcomes and subclinical phenotypes JO - Curr Epidemiol Rep VL - 2 UR - https://doi.org/10.1007/s40471-015-0046-4 DO - 10.1007/s40471-015-0046-4 ID - Smith2015 ER - TY - JOUR AU - Ding, K. AU - Kullo, I. J. PY - 2009 DA - 2009// TI - Genome-wide association studies for atherosclerotic vascular disease and its risk factors JO - Circulation Cardiovascular Genetics VL - 2 UR - https://doi.org/10.1161/CIRCGENETICS.108.816751 DO - 10.1161/CIRCGENETICS.108.816751 ID - Ding2009 ER - TY - JOUR AU - Kullo, I. J. AU - Cooper, L. T. PY - 2010 DA - 2010// TI - Early identification of cardiovascular risk using genomics and proteomics JO - Nat Rev Cardiol VL - 7 UR - https://doi.org/10.1038/nrcardio.2010.53 DO - 10.1038/nrcardio.2010.53 ID - Kullo2010 ER - TY - JOUR AU - Morrison, A. C. AU - Bare, L. A. AU - Chambless, L. E. AU - Ellis, S. G. AU - Malloy, M. AU - Kane, J. P. AU - Pankow, J. S. AU - Devlin, J. J. AU - Willerson, J. T. AU - Boerwinkle, E. PY - 2007 DA - 2007// TI - Prediction of coronary heart disease risk using a genetic risk score: the atherosclerosis risk in communities study JO - Am J Epidemiol VL - 166 UR - https://doi.org/10.1093/aje/kwm060 DO - 10.1093/aje/kwm060 ID - Morrison2007 ER - TY - JOUR AU - Ripatti, S. AU - Tikkanen, E. AU - Orho-Melander, M. AU - Havulinna, A. S. AU - Silander, K. AU - Sharma, A. AU - Guiducci, C. AU - Perola, M. AU - Jula, A. AU - Sinisalo, J. PY - 2010 DA - 2010// TI - A multilocus genetic risk score for coronary heart disease: case-control and prospective cohort analyses JO - Lancet VL - 376 UR - https://doi.org/10.1016/S0140-6736(10)61267-6 DO - 10.1016/S0140-6736(10)61267-6 ID - Ripatti2010 ER - TY - JOUR AU - Thanassoulis, G. AU - Peloso, G. M. AU - Pencina, M. J. AU - Hoffmann, U. AU - Fox, C. S. AU - Cupples, L. A. AU - Levy, D. AU - D’Agostino, R. B. AU - Hwang, S. J. AU - O'Donnell, C. J. PY - 2012 DA - 2012// TI - A genetic risk score is associated with incident cardiovascular disease and coronary artery calcium: the Framingham heart study JO - Circulation Cardiovascular Genetics VL - 5 UR - https://doi.org/10.1161/CIRCGENETICS.111.961342 DO - 10.1161/CIRCGENETICS.111.961342 ID - Thanassoulis2012 ER - TY - JOUR AU - Ganna, A. AU - Magnusson, P. K. AU - Pedersen, N. L. AU - de Faire, U. AU - Reilly, M. AU - Arnlov, J. AU - Sundstrom, J. AU - Hamsten, A. AU - Ingelsson, E. PY - 2013 DA - 2013// TI - Multilocus genetic risk scores for coronary heart disease prediction JO - Arterioscler Thromb Vasc Biol VL - 33 UR - https://doi.org/10.1161/ATVBAHA.113.301218 DO - 10.1161/ATVBAHA.113.301218 ID - Ganna2013 ER - TY - JOUR AU - Tikkanen, E. AU - Havulinna, A. S. AU - Palotie, A. AU - Salomaa, V. AU - Ripatti, S. PY - 2013 DA - 2013// TI - Genetic risk prediction and a 2-stage risk screening strategy for coronary heart disease JO - Arterioscler Thromb Vasc Biol VL - 33 UR - https://doi.org/10.1161/ATVBAHA.112.301120 DO - 10.1161/ATVBAHA.112.301120 ID - Tikkanen2013 ER - TY - JOUR AU - Mega, J. L. AU - Stitziel, N. O. AU - Smith, J. G. AU - Chasman, D. I. AU - Caulfield, M. J. AU - Devlin, J. J. AU - Nordio, F. AU - Hyde, C. L. AU - Cannon, C. P. AU - Sacks, F. M. PY - 2015 DA - 2015// TI - Genetic risk, coronary heart disease events, and the clinical benefit of statin therapy: an analysis of primary and secondary prevention trials JO - Lancet VL - 385 UR - https://doi.org/10.1016/S0140-6736(14)61730-X DO - 10.1016/S0140-6736(14)61730-X ID - Mega2015 ER - TY - JOUR AU - Kullo, I. J. AU - Jouni, H. AU - Austin, E. E. AU - Brown, S. A. AU - Kruisselbrink, T. M. AU - Isseh, I. N. AU - Haddad, R. A. AU - Marroush, T. S. AU - Shameer, K. AU - Olson, J. E. PY - 2016 DA - 2016// TI - Incorporating a genetic risk score into coronary heart disease risk estimates: effect on low-density lipoprotein cholesterol levels (the MI-GENES clinical trial) JO - Circulation VL - 133 UR - https://doi.org/10.1161/CIRCULATIONAHA.115.020109 DO - 10.1161/CIRCULATIONAHA.115.020109 ID - Kullo2016 ER - TY - JOUR AU - Kitano, H. PY - 2004 DA - 2004// TI - Biological robustness JO - Nat Rev Genet VL - 5 UR - https://doi.org/10.1038/nrg1471 DO - 10.1038/nrg1471 ID - Kitano2004 ER - TY - JOUR AU - Khera, A. V. AU - Emdin, C. A. AU - Drake, I. AU - Natarajan, P. AU - Bick, A. G. AU - Cook, N. R. AU - Chasman, D. I. AU - Baber, U. AU - Mehran, R. AU - Rader, D. J. PY - 2016 DA - 2016// TI - Genetic risk, adherence to a healthy lifestyle, and coronary disease JO - N Engl J Med VL - 375 UR - https://doi.org/10.1056/NEJMoa1605086 DO - 10.1056/NEJMoa1605086 ID - Khera2016 ER - TY - JOUR AU - Tang, W. H. AU - Hazen, S. L. PY - 2014 DA - 2014// TI - The contributory role of gut microbiota in cardiovascular disease JO - J Clin Invest VL - 124 UR - https://doi.org/10.1172/JCI72331 DO - 10.1172/JCI72331 ID - Tang2014 ER - TY - JOUR AU - Ganna, A. AU - Salihovic, S. AU - Sundstrom, J. AU - Broeckling, C. D. AU - Hedman, A. K. AU - Magnusson, P. K. AU - Pedersen, N. L. AU - Larsson, A. AU - Siegbahn, A. AU - Zilmer, M. PY - 2014 DA - 2014// TI - Large-scale metabolomic profiling identifies novel biomarkers for incident coronary heart disease JO - PLoS Genet VL - 10 UR - https://doi.org/10.1371/journal.pgen.1004801 DO - 10.1371/journal.pgen.1004801 ID - Ganna2014 ER - TY - JOUR AU - Wang, Z. AU - Klipfell, E. AU - Bennett, B. J. AU - Koeth, R. AU - Levison, B. S. AU - Dugar, B. AU - Feldstein, A. E. AU - Britt, E. B. AU - Fu, X. AU - Chung, Y. M. PY - 2011 DA - 2011// TI - Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease JO - Nature VL - 472 UR - https://doi.org/10.1038/nature09922 DO - 10.1038/nature09922 ID - Wang2011 ER - TY - JOUR AU - Koeth, R. A. AU - Wang, Z. AU - Levison, B. S. AU - Buffa, J. A. AU - Org, E. AU - Sheehy, B. T. AU - Britt, E. B. AU - Fu, X. AU - Wu, Y. AU - Li, L. PY - 2013 DA - 2013// TI - Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis JO - Nat Med VL - 19 UR - https://doi.org/10.1038/nm.3145 DO - 10.1038/nm.3145 ID - Koeth2013 ER - TY - JOUR AU - Stella, C. AU - Beckwith-Hall, B. AU - Cloarec, O. AU - Holmes, E. AU - Lindon, J. C. AU - Powell, J. AU - van der Ouderaa, F. AU - Bingham, S. AU - Cross, A. J. AU - Nicholson, J. K. PY - 2006 DA - 2006// TI - Susceptibility of human metabolic phenotypes to dietary modulation JO - J Proteome Res VL - 5 UR - https://doi.org/10.1021/pr060265y DO - 10.1021/pr060265y ID - Stella2006 ER - TY - JOUR AU - Wurtz, P. AU - Havulinna, A. S. AU - Soininen, P. AU - Tynkkynen, T. AU - Prieto-Merino, D. AU - Tillin, T. AU - Ghorbani, A. AU - Artati, A. AU - Wang, Q. AU - Tiainen, M. PY - 2015 DA - 2015// TI - Metabolite profiling and cardiovascular event risk: a prospective study of 3 population-based cohorts JO - Circulation VL - 131 UR - https://doi.org/10.1161/CIRCULATIONAHA.114.013116 DO - 10.1161/CIRCULATIONAHA.114.013116 ID - Wurtz2015 ER - TY - JOUR AU - Jaffer, F. A. AU - Weissleder, R. PY - 2004 DA - 2004// TI - Seeing within: molecular imaging of the cardiovascular system JO - Circ Res VL - 94 UR - https://doi.org/10.1161/01.RES.0000119321.18573.5A DO - 10.1161/01.RES.0000119321.18573.5A ID - Jaffer2004 ER - TY - JOUR AU - Topol, E. J. PY - 2014 DA - 2014// TI - Individualized medicine from prewomb to tomb JO - Cell VL - 157 UR - https://doi.org/10.1016/j.cell.2014.02.012 DO - 10.1016/j.cell.2014.02.012 ID - Topol2014 ER - TY - STD TI - Trans-Omics for Precision Medicine (TOPMed) Program [https://www.nhlbi.nih.gov/research/resources/nhlbi-precision-medicine-initiative/topmed]. UR - https://www.nhlbi.nih.gov/research/resources/nhlbi-precision-medicine-initiative/topmed ID - ref128 ER - TY - STD TI - FAMILIA -http://www.mountsinai.org/care/heart/familia 2014. UR - http://www.mountsinai.org/care/heart/familia ID - ref129 ER - TY - STD TI - Congress US: Affordable Care Act (ACA). In. Edited by https://www.healthcare.gov/glossary/affordable-care-act/. Washington, DC, : Congress of the United States; 2010. UR - https://www.healthcare.gov/glossary/affordable-care-act ID - ref130 ER - TY - BOOK AU - Lizza, R. PY - 2017 DA - 2017// TI - Why John McCain killed Obamacare repeal—again. In: The New Yorker. Vol. September 22 PB - New York, NY CY - Condé Nast ID - Lizza2017 ER - TY - STD TI - CMS: Information on Essential Health Benefits (EHB) Benchmark Plans. In. Edited by https://www.cms.gov/cciio/resources/data-resources/ehb.html. Washington, DC: Centers for Medicare & Medicaid Services; 2017. UR - https://www.cms.gov/cciio/resources/data-resources/ehb.html ID - ref132 ER - TY - STD TI - HHS FY 2018 Budget in Brief. In. Edited by https://www.hhs.gov/about/budget/fy2018/budget-in-brief/index.html. Washington, DC Department of Health and Human Services; 2017. UR - https://www.hhs.gov/about/budget/fy2018/budget-in-brief/index.html ID - ref133 ER - TY - STD TI - Congress US: H.R.34 - 21st Century Cures Act. In. Edited by https://www.congress.gov/bill/114th-congress/house-bill/34/text?q=%7B%22search%22%3A%5B%2221st+century+cures+act+hr+6%22%5D%7D. Washington, DC Congress of the United States; 2015. UR - https://www.congress.gov/bill/114th-congress/house-bill/34/text?q=%7B%22search%22%3A%5B%2221st+century+cures+act+hr+6%22%5D%7D ID - ref134 ER - TY - JOUR AU - Collins, F. S. AU - Varmus, H. PY - 2015 DA - 2015// TI - A new initiative on precision medicine JO - N Engl J Med VL - 372 UR - https://doi.org/10.1056/NEJMp1500523 DO - 10.1056/NEJMp1500523 ID - Collins2015 ER - TY - STD TI - HealthPeople.gov 2017 [https://www.healthypeople.gov/2020/topics-objectives/topic/genomics]. UR - https://www.healthypeople.gov/2020/topics-objectives/topic/genomics ID - ref136 ER - TY - STD TI - Lazarus D: ‘Big data’ could mean big problems for people's healthcare privacy. In: LA Times Online http://wwwlatimescom/business/lazarus/la-fi-lazarus-big-data-healthcare-20161011-snap-storyhtml. latimes.com: Los Angeles Times; Oct 11 2016. ID - ref137 ER - TY - JOUR AU - Murdoch, T. B. AU - Detsky, A. S. PY - 2013 DA - 2013// TI - The inevitable application of big data to health care JO - JAMA VL - 309 UR - https://doi.org/10.1001/jama.2013.393 DO - 10.1001/jama.2013.393 ID - Murdoch2013 ER - TY - STD TI - Schultz D. As patients’ records go digital, theft and hacking problems grow. In Edited by News KH: KHN. 2012, June;3 ID - ref139 ER - TY - STD TI - Newcomb A: Massive Equifax Data Breach Could Affect Half of the U.S. Population. In: Tech>Security. NBC News; 2017, September 10. ID - ref140 ER - TY - STD TI - Health Information Privacy https://www.hhs.gov/hipaa/index.html 2017. UR - https://www.hhs.gov/hipaa/index.html ID - ref141 ER - TY - STD TI - The Genetic Information Nondiscrimination Act of 2008 https://www.eeoc.gov/laws/statutes/gina.cfm UR - https://www.eeoc.gov/laws/statutes/gina.cfm ID - ref142 ER - TY - JOUR AU - Sander, J. D. AU - Joung, J. K. PY - 2014 DA - 2014// TI - CRISPR-Cas systems for editing, regulating and targeting genomes JO - Nat Biotechnol VL - 32 UR - https://doi.org/10.1038/nbt.2842 DO - 10.1038/nbt.2842 ID - Sander2014 ER - TY - JOUR AU - Baltimore, D. AU - Berg, P. AU - Botchan, M. AU - Carroll, D. AU - Charo, R. A. AU - Church, G. AU - Corn, J. E. AU - Daley, G. Q. AU - Doudna, J. A. AU - Fenner, M. PY - 2015 DA - 2015// TI - Biotechnology. A prudent path forward for genomic engineering and germline gene modification JO - Science VL - 348 UR - https://doi.org/10.1126/science.aab1028 DO - 10.1126/science.aab1028 ID - Baltimore2015 ER - TY - JOUR AU - Schaefer, K. A. AU - WH, W. AU - Colgan, D. F. AU - Tsang, S. H. AU - Bassuk, A. G. AU - Mahajan, V. B. PY - 2017 DA - 2017// TI - Unexpected mutations after CRISPR-Cas9 editing in vivo JO - Nat Methods VL - 14 UR - https://doi.org/10.1038/nmeth.4293 DO - 10.1038/nmeth.4293 ID - Schaefer2017 ER - TY - STD TI - Net Neutrality Debate and Connected Health http://www.cchpca.org/sites/default/files/resources/Net%20Neutrality%20Debate%20and%20Connected%20Health%20FINAL_0.pdf [HHS, Washington, DC ]. UR - http://www.cchpca.org/sites/default/files/resources/Net%20Neutrality%20Debate%20and%20Connected%20Health%20FINAL_0.pdf ID - ref146 ER - TY - STD TI - What is the cost of genetic testing, and how long does it take to get the results? https://ghr.nlm.nih.gov/primer/testing/costresults2017 2017. UR - https://ghr.nlm.nih.gov/primer/testing/costresults2017 ID - ref147 ER - TY - STD TI - Ramsey L: I tried 23andMe's new genetics test — and now I know why the company caused such a stir. In: Science. Business Insider http://www.businessinsider.com/i-tried-the-new-23andme-genetic-test-2015-12/ - a-few-days-after-ordering-my-box-arrived-it-was-colorful-and-so-inviting-that-i-couldnt-wait-to-open-it-up-1; Dec 23 2015. UR - http://www.businessinsider.com/i-tried-the-new-23andme-genetic-test-2015-12 ID - ref148 ER - TY - STD TI - What is direct-to-consumer genetic testing? https://ghr.nlm.nih.gov/primer/testing/directtoconsumer 2017. UR - https://ghr.nlm.nih.gov/primer/testing/directtoconsumer ID - ref149 ER - TY - JOUR AU - Marmot, M. AU - Friel, S. AU - Bell, R. AU - Houweling, T. A. AU - Taylor, S. PY - 2008 DA - 2008// TI - Commission on social determinants of H: closing the gap in a generation: health equity through action on the social determinants of health JO - Lancet VL - 372 UR - https://doi.org/10.1016/S0140-6736(08)61690-6 DO - 10.1016/S0140-6736(08)61690-6 ID - Marmot2008 ER - TY - JOUR AU - Hurd, M. D. AU - Martorell, P. AU - Langa, K. M. PY - 2013 DA - 2013// TI - Monetary costs of dementia in the United States JO - N Engl J Med VL - 369 UR - https://doi.org/10.1056/NEJMc1305541 DO - 10.1056/NEJMc1305541 ID - Hurd2013 ER - TY - JOUR AU - Etters, L. AU - Goodall, D. AU - Harrison, B. E. PY - 2008 DA - 2008// TI - Caregiver burden among dementia patient caregivers: a review of the literature JO - J Am Acad Nurse Pract VL - 20 UR - https://doi.org/10.1111/j.1745-7599.2008.00342.x DO - 10.1111/j.1745-7599.2008.00342.x ID - Etters2008 ER - TY - JOUR AU - Schulz, R. AU - Sherwood, P. R. PY - 2008 DA - 2008// TI - Physical and mental health effects of family caregiving JO - Am J Nurs VL - 108 UR - https://doi.org/10.1097/01.NAJ.0000336406.45248.4c DO - 10.1097/01.NAJ.0000336406.45248.4c ID - Schulz2008 ER - TY - STD TI - Million Hearts (https://millionhearts.hhs.gov/). UR - https://millionhearts.hhs.gov/ ID - ref154 ER - TY - JOUR AU - Benjamin, R. M. PY - 2012 DA - 2012// TI - The million hearts initiative: progress in preventing heart attacks and strokes JO - Public Health Rep VL - 127 UR - https://doi.org/10.1177/003335491212700602 DO - 10.1177/003335491212700602 ID - Benjamin2012 ER - TY - JOUR AU - McAlister, F. A. AU - Lawson, F. M. AU - Teo, K. K. AU - Armstrong, P. W. PY - 2001 DA - 2001// TI - Randomised trials of secondary prevention programmes in coronary heart disease: systematic review JO - BMJ VL - 323 UR - https://doi.org/10.1136/bmj.323.7319.957 DO - 10.1136/bmj.323.7319.957 ID - McAlister2001 ER - TY - JOUR AU - Clark, A. M. AU - Hartling, L. AU - Vandermeer, B. AU - McAlister, F. A. PY - 2005 DA - 2005// TI - Meta-analysis: secondary prevention programs for patients with coronary artery disease JO - Ann Intern Med VL - 143 UR - https://doi.org/10.7326/0003-4819-143-9-200511010-00010 DO - 10.7326/0003-4819-143-9-200511010-00010 ID - Clark2005 ER - TY - JOUR AU - Naylor, M. D. AU - Brooten, D. A. AU - Campbell, R. L. AU - Maislin, G. AU - McCauley, K. M. AU - Schwartz, J. S. PY - 2004 DA - 2004// TI - Transitional care of older adults hospitalized with heart failure: a randomized, controlled trial JO - J Am Geriatr Soc VL - 52 UR - https://doi.org/10.1111/j.1532-5415.2004.52202.x DO - 10.1111/j.1532-5415.2004.52202.x ID - Naylor2004 ER - TY - JOUR AU - Stauffer, B. D. AU - Fullerton, C. AU - Fleming, N. AU - Ogola, G. AU - Herrin, J. AU - Stafford, P. M. AU - Ballard, D. J. PY - 2011 DA - 2011// TI - Effectiveness and cost of a transitional care program for heart failure: a prospective study with concurrent controls JO - Arch Intern Med VL - 171 UR - https://doi.org/10.1001/archinternmed.2011.274 DO - 10.1001/archinternmed.2011.274 ID - Stauffer2011 ER - TY - STD TI - Interprofessional Education Collaborative Expert Panel. Core Competencies for Interprofessional Collaborative Practice: Report of an Expert Panel. In. Washington, DC https://evolve.elsevier.com/education/pdf/IPE_Trend_Perspective_2014.pdf 1–56. UR - https://evolve.elsevier.com/education/pdf/IPE_Trend_Perspective_2014.pdf ID - ref160 ER - TY - JOUR AU - Engel, G. L. PY - 1977 DA - 1977// TI - The need for a new medical model: a challenge for biomedicine JO - Science VL - 196 UR - https://doi.org/10.1126/science.847460 DO - 10.1126/science.847460 ID - Engel1977 ER - TY - STD TI - Benson M, Gustafsson M, Kirschner M, Westerhoff H, Zoppoli G. CASyM ICSB2013 Training workshop report – should systems medical training be integrated for basic and clinical researchers? In: The Road to Systems Medicine: 3 Sep 2013 2013; Copenhagen, Denmark. CASyM administrative office, Project Management Jülich, Forschungszentrum Jülich GmbH. p. 1–11. ID - ref162 ER - TY - JOUR AU - Louis, D. N. AU - Feldman, M. AU - Carter, A. B. AU - Dighe, A. S. AU - Pfeifer, J. D. AU - Bry, L. AU - Almeida, J. S. AU - Saltz, J. AU - Braun, J. AU - Tomaszewski, J. E. PY - 2016 DA - 2016// TI - Computational pathology: a path ahead JO - Arch Pathol Lab Med VL - 140 UR - https://doi.org/10.5858/arpa.2015-0093-SA DO - 10.5858/arpa.2015-0093-SA ID - Louis2016 ER - TY - JOUR AU - Roth, K. A. AU - Almeida, J. S. PY - 2015 DA - 2015// TI - Coming into focus: computational pathology as the new big data microscope JO - Am J Pathol VL - 185 UR - https://doi.org/10.1016/j.ajpath.2015.01.002 DO - 10.1016/j.ajpath.2015.01.002 ID - Roth2015 ER - TY - JOUR AU - Dutta-Moscato, J. AU - Gopalakrishnan, V. AU - Lotze, M. T. AU - Becich, M. J. PY - 2014 DA - 2014// TI - Creating a pipeline of talent for informatics: STEM initiative for high school students in computer science, biology, and biomedical informatics JO - J Pathol Inform VL - 5 UR - https://doi.org/10.4103/2153-3539.129448 DO - 10.4103/2153-3539.129448 ID - Dutta-Moscato2014 ER -