Fig. 1

Systems Healthcare: A New Paradigm. Depicted from left upper corner and proceeding clockwise is the clinical care model with embedded clinical research that generates conventional clinical and imaging data, new biology (‘omic) data and linked non-traditional data as from social media. Data mining and reduction utilizing high performance computing and informatics analyses results in risk stratification, more precise diagnoses and prognoses, these latter reflecting gene-environmental interaction(s) and arriving at patient specific data reduction which can better inform the next cycle of encounter with the patient. In each of the colored arrows there are derivative benefits as shown in blue (non-pharmacological interventions), (new networks to discovery additional druggable targets) and green (new biological insights)