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Table 2 Top ten nodes with the highest values of centrality indices in the pathway-based protein association network

From: Analysis of the main active ingredients and bioactivities of essential oil from Osmanthus fragrans Var. thunbergii using a complex network approach

No. a Protein name b Cd c No. Protein name Cb d No. Protein name Cc e
175 EGFR 0.411 166 PGH2 0.177 207 KPCA 0.500
149 ADRB1 0.404 234 PP2BA 0.109 126 MK01 0.496
156 BKRB2 0.404 207 KPCA 0.093 232 MK03 0.496
170 DRD1 0.404 252 HCD2 0.082 234 PP2BA 0.496
194 ACM3 0.404 126 MK01 0.082 175 EGFR 0.447
195 ACM2 0.404 232 MK03 0.082 149 ADRB1 0.445
197 ACM5 0.404 175 EGFR 0.069 156 BKRB2 0.445
198 ACM1 0.404 282 TYRO 0.049 170 DRD1 0.445
209 5HT2C 0.404 192 AOFA 0.036 194 ACM3 0.445
210 5HT2A 0.404 261 ADH1B 0.027 195 ACM2 0.445
  1. aNumber of nodes are listed in Additional file 2; b Names of the target proteins are uniformed by Uniprot; c Cd represents values of degree centrality; d Cb represents values of betweenness centrality; e Cc represents values of closeness centrality