Analysis of the main active ingredients and bioactivities of essential oil from Osmanthus fragrans Var. thunbergii using a complex network approach

Table 2 Top ten nodes with the highest values of centrality indices in the pathway-based protein association network

No. ^a	Protein name ^b	C_d ^c	No.	Protein name	C_b ^d	No.	Protein name	C_c ^e
175	EGFR	0.411	166	PGH2	0.177	207	KPCA	0.500
149	ADRB1	0.404	234	PP2BA	0.109	126	MK01	0.496
156	BKRB2	0.404	207	KPCA	0.093	232	MK03	0.496
170	DRD1	0.404	252	HCD2	0.082	234	PP2BA	0.496
194	ACM3	0.404	126	MK01	0.082	175	EGFR	0.447
195	ACM2	0.404	232	MK03	0.082	149	ADRB1	0.445
197	ACM5	0.404	175	EGFR	0.069	156	BKRB2	0.445
198	ACM1	0.404	282	TYRO	0.049	170	DRD1	0.445
209	5HT2C	0.404	192	AOFA	0.036	194	ACM3	0.445
210	5HT2A	0.404	261	ADH1B	0.027	195	ACM2	0.445

^aNumber of nodes are listed in Additional file 2; ^b Names of the target proteins are uniformed by Uniprot; ^c C_d represents values of degree centrality; ^d C_b represents values of betweenness centrality; ^e C_c represents values of closeness centrality

ISSN: 1752-0509