Map | Major Process | - log (P) | DEGs | In dendritic data | In THP-1 data |
---|---|---|---|---|---|
Attenuation of IFN type I signaling in melanoma cells | Cancer | 8.53 | 17 | Y | N |
Bacterial infections in CF airways | CF pathways | 7.66 | 18 | N | Y |
Role of PKR in stress-induced antiviral cell response | Immune response | 6.41 | 18 | Y | Y |
B cell signaling in hematological malignancies | Immune response | 6.29 | 21 | N | N |
Bacterial infections in normal airways | Immune response | 5.93 | 16 | N | N |
TLR2 and TLR4 signaling pathways | Immune response | 5.82 | 17 | N | Y |
Role of CD8+ Tc1 cells in COPD | COPD | 4.95 | 14 | Y | Y |
SLE genetic marker-specific pathways in B cells | Immune response | 4.74 | 21 | N | Y |
Release of pro-inflammatory mediators and elastolytic enzymes by alveolar macrophages in COPD | COPD | 4.7 | 11 | N | Y |
G-CSF-induced myeloid differentiation | Development | 4.43 | 11 | N | Y |
Inter-cellular relations in COPD (general schema) | COPD | 4.43 | 11 | Y | Y |
IL-1 signaling pathway | Immune response | 4.28 | 13 | N | Y |
Inflammatory mechanisms of pancreatic cancerogenesis | Cancer | 4.25 | 16 | Y | Y |
Antiviral actions of Interferons | Immune response | 4.25 | 14 | N | N |
Role of fibroblasts and keratinocytes in the elicitation phase of allergic contact dermatitis | Dermatitis | 4.25 | 10 | Y | Y |
Inhibitory PD-1 signaling in T cells | Immune response | 4.19 | 14 | Y | N |
Role of iNKT and B cells in T cell recruitment in allergic contact dermatitis | Dermatitis | 4.07 | 12 | N | N |
LRRK2 and immune function in Parkinson’s disease | Parkinson | 4.03 | 9 | N | N |
TLR5, TLR7, TLR8 and TLR9 signaling pathways | Immune response | 4.03 | 13 | N | Y |
Chemokines in inflammation in adipose tissue and liver in obesity, type 2 diabetes and metabolic syndrome X | Immune response | 4.03 | 13 | N | Y |
Neutrophil-derived granule proteins and cytokines in asthma | Asthma | 3.94 | 13 | N | N |
Cigarette smoke-mediated attenuation of antibacterial and antivirus immune response | Immune response | 3.92 | 10 | Y | Y |
Prostate Cancer: candidate susceptibility genes in inflammatory pathways | Cancer | 3.92 | 10 | N | N |
Inhibition of apoptosis in multiple myeloma | Cancer | 3.86 | 11 | Y | N |
SLE genetic marker-specific pathways in antigen-presenting cells (APC) | Immune response | 3.79 | 17 | Y | Y |
Proinflammatory cytokine production by Th17 cells in asthma | Asthma | 3.61 | 13 | N | N |
Antigen presentation by MHC class I, classical pathway | Immune response | 3.53 | 13 | Y | N |
NK cells in allergic contact dermatitis | Dermatitis | 3.43 | 10 | N | Y |
Inflammatory response in ischemia-reperfusion injury during myocardial infarction | Stem cells | 3.36 | 8 | N | Y |
Putative pathways of activation of classical complement system in major depressive disorder | Complement activation | 3.25 | 9 | N | N |
Th1 and Th17 cells in an autoimmune mechanism of emphysema formation in smokers | Signal transduction | 3.25 | 9 | N | Y |
NF-kB activation pathways | Signal transduction | 3.14 | 12 | N | Y |
iNKT cell-keratinocyte interactions in allergic contact dermatitis | Dermatitis | 3.13 | 10 | N | N |
Apo-2 L(TNFSF10)-induced apoptosis in melanoma | Cancer | 2.98 | 11 | Y | Y |
IFN alpha/beta signaling pathway | Immune response | 2.95 | 8 | Y | N |
EGFR signaling pathway | Development | 2.95 | 14 | N | Y |
Th17 cells in CF | CF pathways | 2.95 | 12 | N | N |
ERBB family and HGF signaling in gastric cancer | Cancer | 2.95 | 12 | N | Y |
Interleukins-induced inflammatory signaling in normal and asthmatic airway epithelium | Immune response | 2.95 | 9 | N | N |
Role of keratinocytes and Langerhans cells in skin sensitization | Skin sensitization | 2.87 | 8 | N | N |
Transcription regulation of granulocyte development | Development | 2.87 | 9 | N | Y |
The role of KEAP1/NRF2 pathway in skin sensitization | Skin sensitization | 2.87 | 9 | N | Y |
Activation of ACTH production in pituitary gland in major depressive disorder | Signal transduction | 2.87 | 9 | N | N |
IFN gamma signaling pathway | Immune response | 2.84 | 12 | N | Y |
Memory CD8+ T cells in allergic contact dermatitis | Dermatitis | 2.84 | 10 | N | Y |
MIF in innate immunity response | Immune response | 2.84 | 10 | N | N |
The innate immune response to contact allergens | Immune response | 2.81 | 9 | N | N |
IL-5 signaling via JAK/STAT | Immune response | 2.81 | 12 | Y | Y |
Cytokine-mediated regulation of megakaryopoiesis | Development | 2.81 | 12 | Y | N |
Inflammasome in inflammatory response | Immune response | 2.72 | 9 | N | N |
TLR ligands | Immune response | 2.72 | 9 | N | N |
Rheumatoid arthritis (general schema) | Others | 2.71 | 11 | Y | N |
Apoptotic TNF-family pathways | Apoptosis and survival | 2.7 | 10 | Y | N |
Neutrophil resistance to apoptosis in COPD and proresolving impact of lipid mediators | COPD | 2.64 | 12 | Y | Y |
Regulation of proinflammatory cytokine production by Th2 cells in asthma | Asthma | 2.64 | 10 | N | N |
Role of cell adhesion in vaso-occlusion in Sickle cell disease | Sickle cell disease | 2.64 | 10 | N | N |
Release of pro-inflammatory factors and proteases by alveolar macrophages in asthma | Asthma | 2.64 | 10 | Y | Y |
HMGB1/TLR signaling pathway | Immune response | 2.57 | 9 | N | Y |
Role of TLR signaling in skin sensitization | Skin sensitization | 2.57 | 10 | N | Y |
Inhibition of neutrophil migration by proresolving lipid mediators in COPD | COPD | 2.54 | 13 | N | N |
Role of PKR in stress-induced apoptosis | Apoptosis and survival | 2.54 | 11 | Y | N |
TLRs-mediated IFN-alpha production by plasmacytoid dendritic cells in SLE | SLE | 2.54 | 11 | N | Y |
Role of IFN-beta in activation of T cell apoptosis in multiple sclerosis | Multiple sclerosis | 2.54 | 8 | Y | N |
HSP60 and HSP70/ TLR signaling pathway | Immune response | 2.48 | 11 | N | Y |
T cell receptor signaling pathway | Immune response | 2.41 | 11 | N | N |
Integrin inside-out signaling in T cells | Cell adhesion | 2.39 | 13 | Y | N |
HGF signaling pathway | Development | 2.37 | 10 | Y | N |
Prolactin/ JAK2 signaling in breast cancer | Cancer | 2.32 | 7 | N | Y |
IFN-gamma and Th2 cytokines-induced inflammatory signaling in normal and asthmatic airway epithelium | Asthma | 2.26 | 9 | N | Y |
TNF-alpha and IL-1 beta-mediated regulation of contraction and secretion of inflammatory factors in normal and asthmatic airway smooth muscle | Asthma | 2.26 | 12 | N | Y |
Antigen presentation by MHC class II | Immune response | 2.26 | 5 | N | N |
Integrin inside-out signaling in neutrophils | Cell adhesion | 2.26 | 13 | N | N |
Role of B cells in SLE | SLE | 2.26 | 11 | Y | N |
Th17 cells in CF (mouse model) | CF pathways | 2.26 | 10 | N | N |
LPS-induced platelet activation | Immune response | 2.24 | 7 | N | N |
IL-18 signaling | Immune response | 2.15 | 11 | N | Y |
Inhibition of apoptosis in gastric cancer | Cancer | 2.15 | 9 | Y | Y |
CD8+ Tc1 cells in allergic contact dermatitis | Dermatitis | 2.15 | 7 | Y | N |
Role of IL-8 in colorectal cancer | Cancer | 2.15 | 6 | N | N |
Schema: Initiation of T cell recruitment in allergic contact dermatitis | Dermatitis | 2.15 | 6 | N | N |
Inhibition of WNT5A-dependent non-canonical pathway in colorectal cancer | Cancer | 2.15 | 6 | N | Y |
Function of MEF2 in T lymphocytes | Immune response | 2.15 | 10 | N | Y |
Caspase cascade | Apoptosis and survival | 2.15 | 8 | Y | Y |
Regulation of Tissue factor signaling in cancer | Cancer | 2.1 | 9 | N | N |
Regulatory T cells in murine model of contact hypersensitivity | Others | 2.07 | 7 | N | N |
Production and activation of TGF-beta in airway smooth muscle cells | Signal transduction | 2.07 | 8 | N | N |
Development_Growth hormone signaling via STATs and PLC/IP3 | Development | 2.07 | 8 | N | Y |
Apoptotic pathways and resistance to apoptosis in lung cancer cells | Cancer | 2.04 | 10 | Y | Y |
Cigarette smoke-induced inflammatory signaling in airway epithelial cells | Signal transduction | 2 | 8 | N | Y |
IL-12-induced IFN-gamma production | Immune response | 2 | 8 | N | N |