Table 3 List of 48 DEGs in the meta-analysis proximal to TB-associated SNPs
DEG | Fold change in meta-analysis | FDR P-value in meta-analysis | Most significant SNP | SNP P-value |
|---|---|---|---|---|
SP110 | 1.545 | 8.02e-04 | rs3948464 | 5.90e-37 |
HLA-DPA1 | 1.566 | 7.24e-03 | rs3129750 | 2.51e-22 |
PSMB8 | 1.890 | 5.14e-08 | rs3129750 | 2.51e-22 |
PSMB9 | 2.386 | 3.94e-06 | rs3129750 | 2.51e-22 |
TAP1 | 2.332 | 1.03e-06 | rs3129750 | 2.51e-22 |
TAP2 | 1.918 | 3.54e-04 | rs3129750 | 2.51e-22 |
GBP5 | 3.432 | 1.33e-08 | rs2146340 | 6.90e-19 |
CABIN1 | −1.740 | 3.62e-03 | rs2154594 | 7.31e-19 |
WDR6 | −1.606 | 4.21e-06 | rs1134591 | 1.62e-15 |
SNX10 | 2.000 | 3.23e-06 | rs3814095 | 7.76e-15 |
CD5 | −1.611 | 0.00e + 00 | rs10897125 | 1.01e-14 |
CD6 | −1.940 | 4.95e-03 | rs10897125 | 1.01e-14 |
TIMM10 | 1.971 | 2.16e-08 | rs2649662 | 2.11e-14 |
WARS | 2.345 | 1.99e-07 | rs1009812 | 2.69e-14 |
PSMB10 | 1.793 | 3.97e-05 | rs12102971 | 3.17e-14 |
MS4A4A | 1.882 | 3.51e-06 | rs10750936 | 3.92e-14 |
C2 | 1.823 | 4.89e-12 | rs2532929 | 4.87e-14 |
MICB | 1.580 | 4.85e-04 | rs2532929 | 4.87e-14 |
COX19 | −1.504 | 1.46e-03 | rs11761941 | 4.64e-12 |
FBXO31 | −1.698 | 3.59e-06 | rs10779243 | 8.09e-12 |
LAP3 | 2.956 | 1.33e-08 | rs10939733 | 2.11e-11 |
CIRBP | −1.523 | 6.03e-04 | rs2285899 | 2.41e-11 |
PCSK7 | −1.824 | 8.45e-04 | rs1060211 | 3.98e-11 |
BLK | −1.715 | 7.73e-09 | rs2254546 | 8.30e-11 |
GBP2 | 2.435 | 1.48e-05 | rs12121223 | 3.38e-10 |
GBP3 | 1.561 | 1.46e-04 | rs12121223 | 3.38e-10 |
OAS1 | 1.832 | 3.46e-05 | rs10774671 | 3.72e-10 |
BAZ1A | 1.540 | 3.94e-03 | rs799486 | 4.69e-10 |
ZBTB40 | −1.500 | 6.38e-03 | rs7544210 | 5.12e-10 |
CSTA | 1.771 | 1.14e-04 | rs10934559 | 5.86e-10 |
PBX4 | −1.880 | 6.00e-06 | rs1859287 | 7.42e-10 |
CCR7 | −2.382 | 5.14e-08 | rs11659024 | 7.69e-10 |
C6orf136 | −1.502 | 1.34e-03 | rs1317834 | 1.13e-09 |
MDC1 | −1.595 | 2.24e-09 | rs1317834 | 1.13e-09 |
ITGAM | 1.607 | 5.77e-07 | rs749671 | 1.17e-09 |
CD19 | −1.658 | 1.60e-03 | rs7185232 | 1.21e-09 |
ACSS1 | −1.717 | 7.23e-06 | rs6138553 | 1.79e-09 |
SQRDL | 2.003 | 1.62e-09 | rs1980288 | 2.82e-09 |
SCO2 | 1.909 | 2.96e-03 | rs12148 | 2.92e-09 |
ACTA2 | 1.553 | 8.68e-04 | rs1800682 | 3.81e-09 |
FAS | 1.867 | 7.49e-06 | rs1800682 | 3.81e-09 |
GMFG | 1.836 | 2.11e-03 | rs10412931 | 6.74e-09 |
MAP4K1 | −1.981 | 4.81e-03 | rs10775533 | 8.63e-09 |
ENTPD1 | 1.871 | 2.26e-05 | rs10882657 | 9.31e-09 |
KIF1B | 1.506 | 2.03e-04 | rs11121555 | 2.21e-08 |
PGD | 1.768 | 1.49e-05 | rs11121555 | 2.21e-08 |
EEF1D | −1.584 | 2.57e-03 | rs11136344 | 2.56e-08 |
OLIG1 | −1.528 | 1.13e-05 | rs1044213 | 3.89e-08 |