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Fig. 3 | BMC Systems Biology

Fig. 3

From: Modeling the therapeutic efficacy of NFκB synthetic decoy oligodeoxynucleotides (ODNs)

Fig. 3

a Time courses of NFκB synthetic decoy ODNs and nuclear free NFκB concentrations under different degradation rates (λ s =0.001,0.005,0.02min−1) of synthetic decoy ODNs, under conditions of both no molecular stripping (k s =0 μM−1min−1) and with molecular stripping (k s =10 μM−1min−1). Unbinding rate of synthetic decoy ODNs is set to k soff =1 min−1. b Time courses of NFκB synthetic decoy ODNs and nuclear free NFκB concentrations under different degradation rates (λ s =0.001,0.005,0.02 min−1) of synthetic decoy ODNs, under conditions of both no molecular stripping (k s =0 μM−1min−1) and with molecular stripping (k s =10 μM−1min−1). Unbinding rate of synthetic decoy ODNs is set to k soff =0.02 min−1. The red arrows indicate the duration of action, during which the concentration of nuclear free NFκB does not exceed 0.1 μM

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