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Table 11 List of model equations used in mitochondrial Ca2+ handling (obtained from [10])

From: Composite mathematical modeling of calcium signaling behind neuronal cell death in Alzheimer’s disease

Equation

Biological significance

Mitochondrial uniporter equations

MWC num =(CAC/6)((1+(CAC/6))3)

MWC numerator

MWC denom =((1+(CAC/6))4)+(50/((1+(CAC/0.38))2.8))

MWC denominator

MWC=MWC num /MWC denom

MWC fraction value

\( V^{D}_{uni} = \left (PSI - 91\right)/13.35 \)

Uniporter potential exponent

\( J_{uni} = \left (\rho _{uni} * V^{D}_{uni} * \left (MWC - CAM * exp\left (-V^{D}_{uni}\right)\right)/\left (1 - exp\left (-V^{D}_{uni}\right)\right)\right) * \left (1-PTP_{h}\right) \)

Rate of transport through uniporter considering PTP in high conductance state

Na+/Ca2+ exchanger equations

\( V^{D}_{nc} = exp\left (\left (PSI - 91\right)/53.4\right) \)

Na+/Ca2+ exchanger potential generated

\( J_{nc} = \left (\rho _{nc} * V^{D}_{nc} * \left (1/\left (1 + \left (9.4/30\right)**2\right)\right) * \left (1/\left (1 + \left (0.003 * Dmito/CAM\right)\right)\right)\right) * \left (1-PTP_{h}\right) \)

Rate of Na+/Ca2+ exchange