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Table 11 List of model equations used in mitochondrial Ca2+ handling (obtained from [10])

From: Composite mathematical modeling of calcium signaling behind neuronal cell death in Alzheimer’s disease

Equation Biological significance
Mitochondrial uniporter equations
MWC num =(CAC/6)((1+(CAC/6))3) MWC numerator
MWC denom =((1+(CAC/6))4)+(50/((1+(CAC/0.38))2.8)) MWC denominator
MWC=MWC num /MWC denom MWC fraction value
\( V^{D}_{uni} = \left (PSI - 91\right)/13.35 \) Uniporter potential exponent
\( J_{uni} = \left (\rho _{uni} * V^{D}_{uni} * \left (MWC - CAM * exp\left (-V^{D}_{uni}\right)\right)/\left (1 - exp\left (-V^{D}_{uni}\right)\right)\right) * \left (1-PTP_{h}\right) \) Rate of transport through uniporter considering PTP in high conductance state
Na+/Ca2+ exchanger equations
\( V^{D}_{nc} = exp\left (\left (PSI - 91\right)/53.4\right) \) Na+/Ca2+ exchanger potential generated
\( J_{nc} = \left (\rho _{nc} * V^{D}_{nc} * \left (1/\left (1 + \left (9.4/30\right)**2\right)\right) * \left (1/\left (1 + \left (0.003 * Dmito/CAM\right)\right)\right)\right) * \left (1-PTP_{h}\right) \) Rate of Na+/Ca2+ exchange