Equation | Biological significance |
---|---|
AF1=(1.71e9)∗(ATP m )/(ADP mf ∗pim) | AF1 = affinity bracketed expression |
\( V^{D}_{F1} = exp(0.112 * PSI) \) | ATPase potential generated |
F0/F1 ATPase phosphorylation of ADP m | |
f1=10.5∗AF1 | Variable f1 |
\( f_{2} = 166 * V^{D}_{F1} \) | Variable f2 |
\( f_{3} = (4.85e-12) * A_{F1} * V^{D}_{F1} \) | Variable f3 |
f4=(1e7+0.135∗AF1)∗275 | Variable f4 |
\( f_{5} = (7.74 + (6.65e-8) * A_{F1}) * V^{D}_{F1} \) | Variable f5 |
Jp,F1=−60∗ρF1∗((f1−f2+f3)/(f4+f5)) | Rate of F0/F1 ATPase phosphorylation |
\( J_{H,F1} = -180 * \rho _{F1} * \left (0.213 + f_{1} - 169 * V^{D}_{F1}\right)/\left (f_{4} + f_{5}\right) \) | Proton flux due to ATPase |
JH,leak=ρ leak ∗(PSI+24.6) | Mitochondrial membrane proton leak |
f PDH =1/(1+(1.1∗(1+(15/(1+(CAM/0.05))2)))) | Fraction of activated pyruvate |
J red =Jred,basal+6.3944∗f PDH ∗Jgly,total | NADH reduction rate |
ATP/ADP antiport flux | |
ant1=([ATP4−] i /[ADP3−] i )∗([ADP3−] m /[ATP4−] m )∗exp(−PSI/26.7) | Variable ant1 |
ant2=1+([ATP4−] i /[ADP3−] i )∗exp(−PSI/53.4) | Variable ant2 |
ant3=1+([ADP3−] m /[ATP4−] m ) | Variable ant3 |
J ANT =Jmax,ANT∗((1−ant1)/(ant2∗ant3)) | Rate of Adenine Nucleotide Translocator (ANT) activity |
Phosphorylation of ADP m from TCA cycle | |
Jp,TCA=(Jred,basal/3)+0.84∗f PDH ∗Jgly,total | Unbound, 3- charged mitochondrial ADP concentration |