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Table 15 List of model equations used in calculation of ER Ca2+ handling (modified from [21])

From: Composite mathematical modeling of calcium signaling behind neuronal cell death in Alzheimer’s disease

Equation Biological significance
Jer,out=(VIP3((IP3/(IP3+dIP3))3)((CAC/(CAC+d ACT ))3)(h3)+v leak )(CAERCAC) IP3 receptor and leak
\( J_{serca} = V_{serca} * CAC^{2}/\left (k_{serca}^{2}+CAC^{2}\right) \) SERCA pump
\