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Table 3 List of parameters used in PTP Integration for PTPh and PTPl states [79]

From: Composite mathematical modeling of calcium signaling behind neuronal cell death in Alzheimer’s disease

Parameters

Value

Biological significance

C A M

4 μM

Threshold Mitochondrial Ca2+

y

0.8

Secondary process threshold

\(f_{H_{M}} \)

1.28 x 10 −6

Fast buffering constant for protons in mitochondria

p 1

0.022

Parameter p1

p 2

0.0001

Parameter p2

p 3

0.0231

Parameter p3

p 4

0.0001

Parameter p4

a m p τ

26000

Amplitude for time constant

p 6

0.001

Parameter p6

\(perm_{l}^{H}\)

3.0

PTP Permeability to protons

p e r m Ca

0.4

PTP Permeability to calcium ions

postptp

2

PTP opening indication constant