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Table 5 List of initial conditions [79]

From: Composite mathematical modeling of calcium signaling behind neuronal cell death in Alzheimer’s disease

Parameters Value Biological significance
PSI(0) 164 mV Base potential at time 0
CAM(0) 0.05 μM Mitochondrial Ca2+ concentration at time 0
CAC(0) 0.05 μM Cytosolic Ca2+ concentration at time 0
CAER(0) 11 μM ER Ca2+ concentration at time 0
ADP m (0) 4.46 mM Mitochondrial ADP concentration at time 0
ADP i (0) 0.028 mM Cytosolic ADP concentration at time 0
NADH m (0) 0.16 mM Mitochondrial NADH concentration at time 0
h(0) 95% Percentage of closed channels at time 0
a(0) 0 mM β-amyloid concentration at time 0
y(0) 0 Secondary slow process involved in PTP opening at time 0
PTP h (0) 0 PTP closed at time 0
PTP l (0) 0 PTP closed at time 0
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